Keywords: Sophoridine; Topoisomerase I; Camptothecin; Schiff base; Antitumor activity;
مقالات ISI (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: 2,5-DXP; 2,5-diketopiperazine; ACC; adenoid cystic carcinomas; BBR; berberine; BET; bromodomain and extraterminal; CA; chebulagic acid; CPT; camptothecin; EMT; epithelial-mesenchymal transition; GSK3; glycogen synthase kinase 3-; HCC; hepatocellular carci
Keywords: Topoisomerase I; Topoisomerase IIα; HER2; Genomic profiling; Solid tumors;
Techniques for biological fingerprinting of traditional Chinese medicine
Keywords: Biological fingerprinting; Traditional Chinese medicine; Ultrafiltration; Cell membrane chromatography; Immobilized nanoparticles; Capillary electrophoresis; Adsorbed hollow fibers; Two-dimensional turbulent flow chromatography; BF; biological fingerprint
Keywords: Evodiamine derivatives; Topoisomerase I; Topoisomerase II; Asymmetric synthesis; Antitumor activity
Probing the evolutionary conserved residues Y204, F259, S400 and W590 that shape the catalytic groove of human TDP1 for 3â²- and 5â²-phosphodiester-DNA bond cleavage
Keywords: hTDP1; human tyrosyl-DNA phosphodiesterase 1; TOP1; topoisomerase I; TOP2; topoisomerase II; TOP1cc; TOP1 cleavage complex; TOP2cc; TOP2 cleavage complex; DNA damage and repair; 3â²-End blocking DNA lesions; 5â²-End blocking DNA lesions; Topoisomerases;
Co(III) complexes based on α-N-heterocyclic thiosemicarbazone ligands: DNA binding, DNA cleavage, and topoisomerase I/II inhibitory activity studies
Keywords: Thiosemicarbazones; Cobalt(III) complexes; Topoisomerase I; Topoisomerase II; DNA interactions;
A polysaccharide from Antrodia cinnamomea mycelia exerts antitumor activity through blocking of TOP1/TDP1-mediated DNA repair pathway
Keywords: Antrodia cinnamomea polysaccharide; Fungal mycelia; Antitumor activity; Apoptosis; Topoisomerase I; Tyrosyl-DNA phosphodiesterase I;
Synthesis of DNA interactive C3-trans-cinnamide linked β-carboline conjugates as potential cytotoxic and DNA topoisomerase I inhibitors
Keywords: β-Carbolines; Trans-cinnamides; DNA intercalation; Topoisomerase I; Anticancer activity;
Effect of structural factors on release profiles of camptothecin from block copolymer conjugates with high load of drug
Keywords: Block copolymer conjugates; Camptothecin; Polylactide; Atom transfer radical polymerization; PEG methacrylate; Drug release kinetics models; ATRP; atom transfer radical polymerization; CC-; conventional calibration (narrow polystyrene standards); CPT; cam
Effects of camptothecin or TOP1 overexpression on genetic stability in Saccharomyces cerevisiae
Keywords: Topoisomerase I; Campthothecin; Mutagenesis; Recombination; Yeast;
Synthesis, insecticidal activity and inhibition on topoisomerase I of 20(S)-t-Boc-amino acid derivatives of camptothecin
Keywords: Camptothecin derivatives; Spodoptera exigua; Contact activity; Cytotoxicity; Topoisomerase I;
The Top1 paradox: Friend and foe of the eukaryotic genome
Keywords: Top1; topoisomerase I; DSB; double-strand break; RNAP; RNA polymerase; GCR; gross chromosomal rearrangement; CPT; camptothecin; G4; guanine quadruplex; TNR; trinucleotide repeat; CSR; class-switch recombination; AID; activation-induced cytosine deaminase;
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin
Keywords: Quercetin; 10-Hydroxy camptothecin; Cancer therapeutic; Topoisomerase I; Cell cycle; Apoptosis;
Novel water soluble morpholine substituted Zn(II) phthalocyanine: Synthesis, characterization, DNA/BSA binding, DNA photocleavage and topoisomerase I inhibition
Keywords: BSA-binding; DNA-binding; DNA-photocleavage; Phthalocyanines; Topoisomerase I;
3-[(E)-(acridin-9â²-ylmethylidene)amino]-1-substituted thioureas and their biological activity
Keywords: Acridine; Thiosemicarbazone; DNA-binding; Topoisomerase I; Spectroscopic study;
Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors
Keywords: Furan-2(5H)-one; α, β-unsaturated lactones; Topoisomerase I; Antitumor;
Negatively-charged amino acids at the peptide-binding pocket of HLA-DPB1 alleles are associated with susceptibility to anti-topoisomerase I-positive systemic sclerosis
Keywords: Systemic sclerosis; HLA; Topoisomerase I; Epitope
Design, synthesis and biological evaluation of lapachol derivatives possessing indole scaffolds as topoisomerase I inhibitors
Keywords: WVWZDUZSNYDZHH-UHFFFAOYSA-N; WNVLVESSJIQBDA-UHFFFAOYSA-N; OIPVNVUYHWFWKU-UHFFFAOYSA-N; CHKHITCFNJDQBB-UHFFFAOYSA-N; ZTJOAMULLFTRLP-UHFFFAOYSA-N; NNXPCSUYLLFIMP-UHFFFAOYSA-N; HMOCMMSHXMENBG-UHFFFAOYSA-N; PDRHPQXIVFDWOC-UHFFFAOYSA-N; GNJJTVWRDDUQJF-UHFFFAOY
Alteration in DNA binding pattern of conformationally locked NC(O)N system: A spectroscopic investigation
Keywords: Deoxyribonucleic acid; Fluorescence; Stern–Volmer quenching constant; Circular dichroism; Topoisomerase I
A simplified protocol for high-yield expression and purification of bacterial topoisomerase I
Keywords: Type IA topoisomerase; Topoisomerase I; Streptococcus mutans; Purification; Characterization; Autoinduction; SmTopI; Streptococcus mutans topoisomerase I; VGS; Viridans Group Streptococci; VGSS; Viridans Group Streptococcal Shock Syndrome; SmTopA15b; Stre
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects
Keywords: Baicalein; 10-hydroxy camptothecin; Anti-cancer; Topoisomerase I; p53; Apoptosis; BA; baicalein (5, 6, 7-trihydroxyflavone); CI; combination index; CPT; camptothecin derivative; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; GAPDH; glyce
Human Topoisomerase I mediated cytotoxicity profile of l-valine-quercetin diorganotin(IV) antitumor drug entities
Keywords: Quercetin pharmacophore; L-/d-valine; Organotin(IV); In vitro DNA binding studies; Denaturation; pBR322 cleavage; Topo I inhibition; Cytotoxic activity; CD; Circular dichroism; CT-DNA; Calf thymus DNA; Q; Quercetin; Topo I; Topoisomerase I; EB; Ethidiu
Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity
Keywords: [1,5]-Naphthyridines; Topoisomerase I; Enzyme inhibition; Antiproliferative effect; CCK8; cell counting kit; CPT; camptothecin; CPTs; camptothecin derivatives; DDQ; dichloro-5,6-dicyanobenzoquinone; HDAr; hetero-Diels-Alder reaction; MCR; multicomponent r
Novel securinine derivatives as topoisomerase I based antitumor agents
Keywords: Securinine derivatives; Baylis-Hillman reaction; Topoisomerase I; Antitumor agent
Enantiomeric pair of copper(II) polypyridyl-alanine complexes: Effect of chirality on their interaction with biomolecules
Keywords: Ternary copper(II) complexes; Chirality; Deoxyribonucleic acid; Restriction enzyme; Topoisomerase I; Proteasome;
Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIα inhibitory activity
Keywords: 5Z,9Z-Dienoic acids; DNA-binding; Topoisomerase I; Topoisomerase IIα; Molecular docking
DNA-Topoisomerase I, a new target for the treatment of neuroblastoma
Keywords: topoisomerase I; irinotecan; topotecan; neuroblastoma; xenografts
Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations
Keywords: Nothapodytes nimmoniana; Icacinaceae; Topoisomerase I; Camptothecin; Resistance; Mutation;
Topoisomerase I deficiency causes RNA polymerase II accumulation and increases AID abundance in immunoglobulin variable genes
Keywords: DT40; Topoisomerase I; RNA polymerase II; Activation-induced deaminase; Somatic hypermutation; Gene conversion;
Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents
Keywords: Acridine; Benzimidazole; DNA; Topoisomerase I; Antitumor
Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue
Keywords: Lung cancer; Topoisomerase I; Tyrosyl-DNA phosphodiesterase 1; Biosensor; Cryosection;
Antiproliferative and apoptosis-inducing activities of novel naphthalimide-cyclam conjugates through dual topoisomerase (topo) I/II inhibition
Keywords: Naphthalimide-cyclam conjugates; Antitumor agents; Topoisomerase I; Topoisomerase II; DNA intercalation; Apoptosis;
Molecular modelling approach to evaluate poisoning of topoisomerase I by alternariol derivatives
Keywords: AOH; alternariol; AME; alternariol-methyl ether; ALT; altenuene; iALT; isoaltenuene; LBVS; ligand based virtual screening; Topo; topoisomerase; Topo I; topoisomerase I; Topo II; topoisomerase II; Molecular modelling; Alternaria metabolites; Alternariol; P
Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target
Keywords: Mycobacterium tuberculosis; Topoisomerase I; Essential; Knockdown; Vulnerable; Anziaic acid; Phenotypic screening;
Inhibition of human topoisomerase I and II and anti-proliferative effects on MCF-7 cells by new titanocene complexes
Keywords: DMSO; dimethyl sulfoxide; THF; tetrahydrofuran; ADP; adenosine diphosphate; ATP; adenosine triphosphate; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM/F-12; Dulbecco's modified eagle medium: nutrient mixture F-12; DNA; deoxyribonucleic acid; EDTA; ethylen
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity
Keywords: Topoisomerase I; Thiohydantoin; Hydantoin; Methylfuro[3,4-c]pyridine-3,4(1H,5H)-dione; Camptothecin; Leishmania bi-subunit topoisomerase I
Identification of potential Mycobacterium tuberculosis topoisomerase I inhibitors: A study against active, dormant and resistant tuberculosis
Keywords: Tuberculosis; Mycobacterium tuberculosis; Topoisomerase I
Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents
Keywords: Acridone; Pyridyl; Molecular docking; DNA; Topoisomerase I; Antitumor
Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors
Keywords: Benzo[a]phenazin derivatives; Topoisomerase I; Topoisomerase II; ATPase catalytic inhibitor; Antitumor
Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines
Keywords: Dihydroxylated 2,6-diphenyl-4-aryl pyridines; Topoisomerase I; Topoisomerase II; Cytotoxicity; Anticancer agents;
Design, synthesis and biological evaluation of E-ring modified evodiamine derivatives as novel antitumor agents
Keywords: Evodiamine derivatives; Topoisomerase I; Topoisomerase II; Antitumor activity
Role of topoisomerase I and thymidylate synthase expression in sporadic colorectal cancer: Associations with clinicopathological and molecular features
Keywords: Topoisomerase I; Thymidylate synthase; Colorectal cancer; Chromosomal instability; 18qLOH
Zinc (II) complex with a cationic Schiff base ligand: Synthesis, characterization, and biological studies
Keywords: Zinc; Schiff base; Topoisomerase I; DNA cleavage; Cytotoxicity
Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: Interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties
Keywords: Anthra[2,3-b]thiophene-5,10-dione; Telomeric DNA G-quadruplex; Telomerase; Topoisomerase I; Small molecular weight inhibitors; CytotoxicityTelQ, human telomeric G-quadruplex in the presence of potassium ions; FRET, Förster resonance energy transfer; FAM,
Interaction of cholinesterase modulators with DNA and their cytotoxic activity
Keywords: Cholinesterase modulators; Oximes; DNA; Topoisomerase I; HL-60; Cytotoxicity
Synthesis, antitumor activity, and structure–activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors
Keywords: Trihydroxylated 2,4,6-triphenyl pyridines; Topoisomerase I; Topoisomerase II; Topo II inhibitory activity; Cytotoxicity; Anticancer agents; Docking study
Synthesis and structure elucidation of a cobalt(II) complex as topoisomerase I inhibitor: In vitro DNA binding, nuclease and RBC hemolysis
Keywords: CT DNA binding; pBR322 DNA cleavage; T4 DNA ligase assay; Topo I inhibition activity; Molecular docking; UV-Vis; UV-visible; CT DNA; calf thymus DNA; Tris; tris(hydroxymethyl)aminomethane; EB; ethidium bromide; Hmpca; 9-methyl-[1,10]phenanthroline-2-c
Novel N-substituted sophoridinol derivatives as anticancer agents
Keywords: Sophoridinol; Sophoridinic acid; Structure-activity relationship; Antiproliferative; Topoisomerase I;
Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor
Keywords: Topoisomerase I; Topoisomerase II; Cytotoxicity; Anticancer agents; Dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridines; 3D-QSAR