Enantiomeric pair of copper(II) polypyridyl-alanine complexes: Effect of chirality on their interaction with biomolecules

Two pairs of [Cu(phen)(ala)(H2O)]X (phen = 1.10-phenanthroline; ala = alanine; X = Cl−, NO3−) were synthesized and characterized. Effect of chirality on their interactions with various forms of DNA, binding to bovine serum albumin (BSA), and inhibition of restriction enzymes, topoisomerase I and proteasome are presented and discussed.239