دانلود مقالات ISI درباره Topoisomerase I + ترجمه فارسی

Evaluation of trimetallic Ru(II)- and Os(II)-Arene complexes as potential anticancer agents

Keywords: Trimetallic; Cancer; Ruthenium(II)-arenes and osmium(II)-arenes; Cytotoxicity; Topoisomerase I;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors

Keywords: 3-Heteroarylisoquinolinamine; Selective cytotoxicity; Topoisomerase I; Topoisomerase II; Molecular docking; Cell cycle arrest

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Germ cell mutagenicity of topoisomerase I inhibitor topotecan detected in the male mouse-dominant lethal study

Keywords: Dominant lethality; Camptothecins; Topoisomerase I; DNA oxidative stress; N-acetylcysteine; Genomic alterations;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Novel cholinesterase modulators and their ability to interact with DNA

Keywords: Cholinesterase modulators; DNA; Topoisomerase I;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties

Keywords: Tilorone; Fluorenones; Topoisomerase I; NCI 60-cell panel assay;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Keywords: epi; epimer; ent; enantiomer; Quinazolinecarboline alkaloids; Evodiamine; Sirtuins; Topoisomerase I;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents

Keywords: Chalcone; Topoisomerase I; Cytotoxicity; Cathepsin B and L

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Ruthenium (II) complexes containing a new asymmetric ligand: DNA interaction, photocleavage and topoisomerase I inhibition

Keywords: Ru(II) complex; Asymmetric ligand; DNA-binding; Photocleavage; Topoisomerase I

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis of benzo-annulated tryptanthrins and their biological properties

Keywords: Tryptanthrin; Benzotryptanthrin; Topoisomerase I; Topoisomerase II; Isatin; 3-Amino-2-naphthoic acid; Isatoic anhydride; Cytotoxicity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Dithiocarbamate fungicide zineb induces oxidative stress and apoptosis in Chinese hamster lung fibroblasts

Keywords: Glutathione; Lipid peroxidation; Protein oxidation; Topoisomerase I; NAC

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Naturally Occurring Cytotoxic [3′ → 8″]-Biflavonoids from Podocarpus nakaii

Keywords: Podocarpus nakaii; [3′ → 8″]-Biflavonoids; Cytotoxicity; Apoptosis; Topoisomerase I

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation properties and inhibition of its activity

Keywords: Topoisomerase I; Mycobacterium tuberculosis; Toprim motif; DNA relaxation; DNA cleavage;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

MET Increases the Sensitivity of Gefitinib-Resistant Cells to SN-38, an Active Metabolite of Irinotecan, by Up-Regulating the Topoisomerase I Activity

Keywords: Topoisomerase I; MET; Epidermal growth factor receptor-tyrosine kinase inhibitors resistance;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Simple automated radiosynthesis of 10-[11C]methoxy-20(S)-camptothecin and biodistribution in normal mice

Keywords: 10-[11C]methoxy-20(S)-camptothecin; Biodistribution; Micro-PET; Automated radiosynthesis; Topoisomerase I; Carbon-11;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

Keywords: Dihydroxylated 2,4,6-triphenyl pyridines; Topoisomerase I; Topoisomerase II; Cytotoxicity; Anticancer agents

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II

Keywords: Dovitinib; Anticancer; DNA; Topoisomerase II; Topoisomerase I;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Towards a selective cytotoxic agent for prostate cancer: Interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with topoisomerase I

Keywords: Cytotoxicity; Schiff base; Topoisomerase I; Prostate cancer; Zinc; Thiosemicarbazone

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents

Keywords: Acridine; Intercalator; Topoisomerase I; Cytotoxic; Antitumor activity; Caspase-3; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Hsp90 inhibitors sensitise human colon cancer cells to topoisomerase I poisons by depletion of key anti-apoptotic and cell cycle checkpoint proteins

Keywords: Topoisomerase I; Hsp90; P53; Irinotecan; Topotecan; 17AAG

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis, structure-activity relationship and biological evaluation of anticancer activity for novel N-substituted sophoridinic acid derivatives

Keywords: N-Substituted sophoridinic acid; Anticancer activity; Structure-activity relationship; Topoisomerase I; Mechanism;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Survival-strategies of endophytic Fusarium solani against indigenous camptothecin biosynthesis

Keywords: Camptothecin; Endophytic fungus; Fusarium solani; Topoisomerase I; Survival-strategy

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Toward new camptothecins. Part 7: Synthesis of thioluotonin and its 5-methoxycarbonyl derivative

Keywords: Luotonin; Thioluotonin; Camptothecin; Thiocamptothecin; Thiovasicinone; Thiodeoxyvasicinone; Topoisomerase I;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Study of DNA interactions with cyclic chalcone derivatives by spectroscopic techniques

Keywords: UV–vis; CD; Fluorescence spectroscopy; DNA-intercalation; Chalcone; Bovine serum albumin; Topoisomerase I

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors

Keywords: Indeno[1,2-c]isoquinolines; Topoisomerase I; Cytotoxicity; Docking study;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase I inhibitors with molecular modeling

Keywords: 4-Amino-2-phenylquinazolines; Topoisomerase I; Cytotoxicity; Docking study; DNA intercalation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The first series of 4,11-bis[(2-aminoethyl)amino]anthra[2,3-b]furan-5,10-diones: Synthesis and anti-proliferative characteristics

Keywords: Anthra[2,3-b]furan-5,10-diones; Topoisomerase I; Cytotoxicity; Drug resistance; Tumor cells;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Topoisomerase I inactivation by a novel thiol reactive naphthoquinone

Keywords: Topoisomerase I; Chemotherapeutic; Naphthoquinone; Anthracycline; Thiol modification; Inhibitor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Physical and functional interaction between d-ribokinase and topoisomerase I has opposite effects on their respective activity in Mycobacterium smegmatis and Mycobacterium tuberculosis

Keywords: Mycobacterium tuberculosis; Ribokinase; Topoisomerase I; Mycobacterium smegmatis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Pyrrolo[2,3-α]carbazole derivatives as topoisomerase I inhibitors that affect viability of glioma and endothelial cells in vitro and angiogenesis in vivo

Keywords: Angiogenesis; Cancer; Endothelial cells; Glioma; Indolocarbazoles; Pyrrolo[2,3-α]carbazoles; Topoisomerase I

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol

Keywords: Cobalt(II) complexes; DNA binding; Anticancer; Topoisomerase I; Restriction enzyme

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors

Keywords: Synthesis; Mansonone F derivatives; Cytotoxic activity; Topoisomerase I; Topoisomerase II

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of benzo[3,4]azepino[1,2-b]isoquinolin-9-ones from 3-arylisoquinolines via ring closing metathesis and evaluation of topoisomerase I inhibitory activity, cytotoxicity and docking study

Keywords: Benzo[3,4]azepino[1,2-b]isoquinolinone; Ring closing metathesis; 3-Arylisoquinoline; Chemical shift difference; Topoisomerase I; Docking study;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-Aryl-substituted 2-bis-1H-benzimidazoles

Keywords: Bisbenzimidazole; MTT; Hoechst 33342; Antitumor activity; Topoisomerase I; Calf Thymus DNA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

A gene delivery system based on the N-terminal domain of human topoisomerase I

Keywords: Gene delivery system; Protein transduction domain; Topoisomerase I; Membrane penetration domain; DNA binding

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D

Keywords: Lamellarin; Synthesis; Molecular modeling; Topoisomerase I; Antitumor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of new cytotoxic E-ring modified camptothecins

Keywords: Camptothecin; Synthesis; Antitumour activity; Topoisomerase I; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Phase II Randomized Study of Two Regimens of Sequentially Administered Mitomycin C and Irinotecan in Patients with Unresectable Esophageal and Gastroesophageal Adenocarcinoma

Keywords: Gastroesophageal adenocarcinoma; Irinotecan; Mitomycin C; Topoisomerase I

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Parenteral formulation and thermal degradation pathways of a potent rebeccamycin based indolocarbazole topoisomerase I inhibitor

Keywords: Indolocarbazole; Topoisomerase I; Solubility; Cosolvent; PG; Stability; Buffer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin

Keywords: DNA-PK; DNA damage; Camptothecin; Proteasome; Topoisomerase I

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

A new ELISA plate based microtiter well assay for mycobacterial topoisomerase I for the direct screening of enzyme inhibitory monoclonal antibody supernatants

Keywords: MAbs, Monoclonal antibodies; PAb, Polyclonal antibody; Ms, Mycbacterium smegmatis; topo I, topoisomerase IRapid screening; Microtiter plate; Monoclonal antibody; Topoisomerase I; Mycobacteria

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides

Keywords: Triterpenoids; Triterpenoid glycosides; Structure–activity relationship; Topoisomerase I; Cytotoxicity

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Phosphate ester derivatives of homocamptothecin: Synthesis, solution stabilities and antitumor activities

Keywords: Homocamptothecins; Antitumor activity; Topoisomerase I; Phosphate

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91

Keywords: Camptothecin; DB-67; Topoisomerase I; Anticancer activity; Lactone stability; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: Implications for physiological and therapeutic modulation of enzyme activity

Keywords: Camptothecin; Topoisomerase I; RNA polymerase; Transcription pausing; HIF1a;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents

Keywords: Netropsin; DNA; Minor groove; Intercalator; Anthrapyrazole; Anticancer; Topoisomerase I; Topoisomerase II; Cytotoxic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites

Keywords: Common fragile sites; Topoisomerase I; Camptothecin; Replication stress

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

The intergenic region between the Mouse Recql4 and Lrrc14 genes functions as an evolutionary conserved bidirectional promoter

Keywords: AP; Alkaline Phosphatase; BAL1; B-aggressive lymphoma 1; BBAP; B-aggressive lymphoma and BAL1 binding partner; bp; base pair(s); BCIP; 5-Bromo-4-chloro-3-indolyl phosphate toluidine salt; BT; Basal Telencephalon; C; Cytidine; cDNA; complementary DNA; CEI;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2010 سفارش ترجمه

The molecular mechanism regulating the autonomous circadian expression of Topoisomerase I in NIH3T3 cells

Keywords: Topoisomerase I; Circadian rhythms; Promoter analysis; Antitumor drugs; Clock genes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Nick-containing oligonucleotides as human topoisomerase I inhibitors

Keywords: Topo I; topoisomerase I; Oligonucleotide; ON; IC50; the concentration of a drug that is required for 50% inhibition of the activity; Human topoisomerase I; Enzyme inhibitor; Stable hairpins; Nick oligonucleotides;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide

Keywords: TOP1-targeting agents; 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones; Cytotoxic activity; Multidrug resistance; Antitumor; Quaternary ammonium salts; ARC-111; CPT; camptothecin; BCRP; breast cancer resistance protein; MDR1; P-glycoprotein; TOP1; topoisomerase I

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه