کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3099880 | 1191140 | 2012 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Naturally Occurring Cytotoxic [3′ → 8″]-Biflavonoids from Podocarpus nakaii Naturally Occurring Cytotoxic [3′ → 8″]-Biflavonoids from Podocarpus nakaii](/preview/png/3099880.png)
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3′ → 8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as 1H, 13C, 1H-1H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50ca. 4.56-16.24 μg/mL) and induced cell apoptosis in MCF-7 via mainly sub-G1/S phase arrest. Furthermore, these compounds exhibited moderate Topoisomerase I inhibitory activity.
Journal: Journal of Traditional and Complementary Medicine - Volume 2, Issue 3, July–September 2012, Pages 220–226