Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines

Total thirty-six dihydroxylated 2,6-diphenyl-4-aryl pyridines were designed, synthesized and tested for topo I and II inhibitory activity and cytotoxicity for the development of novel anticancer agents.177