کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6273770 1614798 2014 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tetramethylpyrazine promotes SH-SY5Y cell differentiation into neurons through epigenetic regulation of Topoisomerase IIβ
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Tetramethylpyrazine promotes SH-SY5Y cell differentiation into neurons through epigenetic regulation of Topoisomerase IIβ
چکیده انگلیسی

- Tetramethylpyrazine (TMP) promotes SH-SY5Y cell differentiation into neuronal phenotype cell.
- TMP induces neuronal differentiation of SH-SY5Y cell through up-regulating Topoisomerase IIβ (TopoIIβ).
- TMP increases the levels of global acetylated histone H3 and H4 which were positively correlated with TopoIIβ expression.
- Transcriptional activation of TopoIIβ gene is due to hyperacetylation of histone H3 and H4 at its proximal promoter region.
- TMP could be used as a promising candidate in drug-therapy of neuron injuries and neurodegenerative diseases in future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 278, 10 October 2014, Pages 179-193
نویسندگان
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