کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052348 1074228 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Induction of necrotic cell death and mitochondrial permeabilization by heme binding protein 2/SOUL
چکیده انگلیسی

We found that heme-binding protein 2/SOUL sensitised NIH3T3 cells to cell death induced by A23187 and etoposide, but it did not affect reactive oxygen species formation. In the presence of sub-threshold calcium, recombinant SOUL provoked mitochondrial permeability transition (mPT) in vitro that was inhibited by cyclosporine A (CsA). This effect was verified in vivo by monitoring the dissipation of mitochondrial membrane potential. Flow cytometry analysis showed that SOUL promoted necrotic death in A23187 and etoposide treated cells, which effect was prevented by CsA. These data suggest that besides its heme-binding properties SOUL promotes necrotic cell death by inducing mPT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 27, 27 November 2006, Pages 6447–6454
نویسندگان
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