کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052369 | 1074229 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet Oxidative damage of periodontal tissue in the rat periodontitis model: Effects of a high-cholesterol diet](/preview/png/2052369.png)
چکیده انگلیسی
Studies suggest an association between consumption of a high-cholesterol diet and periodontitis. We addressed the mechanism by which high dietary cholesterol could be detrimental to periodontal health in a rat model. Feeding a high-cholesterol diet augmented the effects of bacterial pathogens and their products (e.g., lipopolysaccharide and proteases) on production of pro-inflammatory cytokines in fibroblasts. High dietary cholesterol also increased mitochondrial 8-hydroxydeoxyguanosine in the periodontal tissues. These results suggest that excessive tissue oxidative damage induced by high dietary cholesterol could potentiate pro-inflammatory cytokine production by fibroblasts stimulated with bacterial pathogens.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 15, 26 June 2006, Pages 3601–3604
Journal: FEBS Letters - Volume 580, Issue 15, 26 June 2006, Pages 3601–3604
نویسندگان
Takaaki Tomofuji, Tetsuji Azuma, Hiroki Kusano, Toshihiro Sanbe, Daisuke Ekuni, Naofumi Tamaki, Tatsuo Yamamoto, Tatsuo Watanabe,