کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052416 | 1074230 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: Association with an attenuated CYP2B induction by phenobarbital
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کلمات کلیدی
2-AAF, 2-acetylaminofluorene - 2-AAF، 2-استامینامین فلوئورنCAR, Constitutive Androstane Receptor - CAR، گیرنده اصلی آندروستانGAPDH, glyceraldehyde-3-phosphate dehydrogenase - GAPDH، glyceraldehyde-3-phosphate dehydrogenaseGFP, green fluorescent protein - GFP، پروتئین فلورسنت سبزCYP, cytochrome P450 - سیتوکروم P450
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: Association with an attenuated CYP2B induction by phenobarbital Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: Association with an attenuated CYP2B induction by phenobarbital](/preview/png/2052416.png)
چکیده انگلیسی
Phenobarbital (PB) induction of CYP2B, a representative target gene of constitutive androstane receptor (CAR), has been observed to be attenuated in preneoplastic lesions of rat liver; however, molecular basis for this attenuation is poorly understood. In this report, we provide evidence indicating that the CAR expressed in the hepatic preneoplastic lesions of rats and mice was resistant to nuclear translocation and transactivation of the PB-responsive enhancer module upon PB treatment. These observations suggest that the attenuation of the induction of CYP2B by PB in hepatic preneoplastic lesions is evidently a consequence of impaired nuclear translocation of CAR.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3560–3564
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3560–3564
نویسندگان
Satoshi Numazawa, Sawako Shindo, Keiji Maruyama, Fumika Chibana, Yosuke Kawahara, Takashi Ashino, Sachiko Tanaka, Takemi Yoshida,