Keywords: سیتوکروم P450; Eosinophil; Lipid mediator; Lipidomics; Lipoxygenase; n-3 fatty acidPUFA, polyunsaturated fatty acid; LC-MS/MS, liquid chromatography tandem mass spectrometry; COX, cyclooxygenase; LOX, lipoxygenase; CYP, cytochrome P450; HETE, hydroxy-eicosatetraenoic ac
مقالات ISI سیتوکروم P450 (ترجمه نشده)
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Keywords: سیتوکروم P450; Fatty liver disease; Liver cancer; Western diet; Broccoli; DiethylnitrosamineAHF, altered hepatic foci; ALT, alanine aminotransferase; AMPK, 5' AMP-activated protein kinase; Cyp, cytochrome P450; DEN, diethylnitrosamine; GAPDH, glyceraldehyde 3-phosphate
Keywords: سیتوکروم P450; SUI, stress urinary incontinence; DAT, dopamine transporter; SERT, serotonin transporter; NET, norepinephrine transporter; MDR1, multidrug resistance 1; P-gp, P-glycoprotein; CYP, cytochrome P450; hERG, human ether-a-go-go-related gene K+ channel; CNS, ce
Keywords: سیتوکروم P450; Adipose tissue; Lipid mediators; Omega-6 and omega-3 fatty acidsBAT, brown adipose tissue; COX, cyclooxygenase; CYP, cytochrome P450; DHA, docosahexaenoic acid; EDPs, epoxydocosapentaenoic acids; EEQs, epoxyeicosatetraenoic acids; EETs, epoxyeicosatrienoi
Keywords: سیتوکروم P450; PHIC, Palestinian Health Information Center; CAM, Complementary and alternative medicine; CYP, Cytochrome P450; TAPHM, Traditional Arabic Palestinian Herbal Medicine; IRB, Institutional Review Board; BERC, Biodiversity and Environmental Research Center; E
Keywords: سیتوکروم P450; BiP, immunoglobulin heavy-chain binding protein; BIX, BiP inducer X; CACI, chemotherapy-associated cognitive impairments; CHOP, C/EBP homologous protein; CYP, cytochrome P450; ER, endoplasmic reticulum; Flv, fluvoxamine; JNK, c-Jun NH2-terminal kinase; Px
Keywords: سیتوکروم P450; AED, antiepileptic drugs; CBT, cognitive behavioral therapy; CYP, cytochrome P450; MBRN, Medical Birth Registry of Norway; SSRI, selective serotonin reuptake inhibitor; SNRI, serotonin noradrenaline reuptake inhibitor; WWE, women with epilepsyPerinatal; S
Keywords: سیتوکروم P450; AADAC, arylacetamide deacetylase; CES, carboxylesterase; CYP, cytochrome P450; DMSO, dimethyl sulfoxide; HIM, human intestinal microsomes; HJM, human jejunum microsomes; HLM, human liver microsomes; HPLC, high-performance liquid chromatography; NAT, N-ace
Keywords: سیتوکروم P450; AOC, area over the curve; BBR, benzbromarone; CsA, cyclosporin A; CYP, cytochrome P450; DRLM, dexamethasone-treated Sprague–Dawley rat liver microsome; DILI, Drug-induced liver injury; G6P, glucose 6-phosphate; G6PDH, glucose-6-phosphate dehydrogenase; mt
Keywords: سیتوکروم P450; Warfarin; Clopidogrel; Pharmacogenetic-guided algorithm; Akaike's information criterionACS, acute coronary syndromes; ADP, adenosine diphosphate; AIC, Akaike's Information Criterion; BSA, body surface area; CYP, cytochrome P450; DAPT, dual anti-platelet t
Keywords: سیتوکروم P450; ACS, acute coronary syndrome; ADP, adenosine diphosphate; ASA, aspirin; ATP, adenosine triphosphate; CABG, coronary artery bypass graft; CAD, coronary artery disease; CYP, cytochrome P450; COX, cyclooxygenase; CV, cardiovascular; DAPT, dual antiplatelet t
Keywords: سیتوکروم P450; AGC, automatic gain control; CPR, cytochrome P450 reductase; CYP, cytochrome P450; DW, dry weight; HCD, high-energy collision-induced dissociation; ICP-OES, inductively coupled plasma-optical emission spectroscopy; iTRAQ, isobaric tag for relative and abs
Keywords: سیتوکروم P450; BR, bilirubin; ROS, reactive oxygen species; CYP, cytochrome P450; CYP2A5, cytochrome P450 2A5; HMOX1, heme oxygenase-1; UGT1A1, UDP-glucuronosyltransferase 1A1; BVR, biliverdin reductaseMitochondria; CYP2A5; HMOX1; Bilirubin; Oxidative stress; Endoplasmi
Keywords: سیتوکروم P450; AUC, area under the plasma concentration versus time curve; (B–A)/(A–B), cross-membrane transport rate, basolateral to apical and reverse; CB, covalent binding; CL, clearance; Cmax, maximal plasma concentration; CYP, cytochrome P450; fu, fraction unbound
Keywords: سیتوکروم P450; HSD, hydroxysteroid dehydrogenase; AKR, aldo-ketoreductase; HPA, hypothalamo-pituitary-adrenal; E2, estradiol; LPL, lipoprotein lipase; FFA, free fatty acids; IL, interleukin; TNF-α, tumor necrosis factor alpha; CYP, cytochrome P450; E1, estrone; PPARγ, p
Keywords: سیتوکروم P450; AUC, area under the concentration–time curve; CL, clearance; Cmax, maximum concentration; CYP, cytochrome P450; DDI, drug–drug interaction; F, bioavailability; HMG–CoA, 3-hydroxy-3-methylglutaryl–coenzyme A; Jmax, maximum rate of transporter-mediated effl
Keywords: سیتوکروم P450; Lipid-based anticancer agent; Alkyl phospholipid; PUFA epoxide; Epoxide isostere; Tumor proliferation; Tumor apoptosisAkt, protein kinase B; ALP, alkyl phospholipid; CDK, cyclin-dependent kinase; COX, cyclooxygenase; CYP, cytochrome P450; DHA, docosahexae
Keywords: سیتوکروم P450; BAT, brown adipose tissue; CYP, cytochrome P450; DAG, diacylglycerol; DNP, 2,4-dinitrophenol; FAO, fatty acid oxidation; DNPME, 2,4-dinitrophenol-methyl ether; NAFLD, nonalcoholic fatty liver disease; OXPHOS, oxidative phosphorylation; PKCɛ, protein kinas
Keywords: سیتوکروم P450; CYP, cytochrome P450; LC-MS/MS, liquid chromatography-tandem mass spectrometry; IQR, interquartile range; RSD, relative standard deviationBortezomib; Blood distribution; Multiple myeloma; Pharmacokinetics; Therapeutic drug monitoring
Keywords: سیتوکروم P450; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AMY, amylase; AST, aminotransferase; BUN, blood urea nitrogen; CCl4, carbon tetrachloride; CCl3-radical, trichloromethyl radical; CK, creatine kinase; CRP, C-reactive protein; CYP, cytochrome P450;
Keywords: سیتوکروم P450; Abca1, ATP-binding cassette transporter a1; BA, bile acid; CA, cholic acid; Bsep, bile salt-export pump; CDCA, chenodeoxycholic acid; Cyp, cytochrome P450; DCA, deoxycholic acid; Fxr, farnesoid X receptor; GAPDH, glyceraldehyde 3-phosphate dehydrogenase;
Keywords: سیتوکروم P450; AhR, aryl hydrocarbon receptor; BMR, benchmark response; CYP, cytochrome P450; DLC, dioxin-like compound; EROD, ethoxyresorufin-O-deethylase; HepG2, human hepatoblastoma cell line; 1234678-HpCDD, 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin; 123678-HxCDD, 1,
Keywords: سیتوکروم P450; CYP, cytochrome P450; DDI, drug–drug interactions; DPM, disintegrations per minute; HCV, hepatitis C virus; HLM, human liver microsomes; PBPK, Physiologically-based pharmacokinetics; PK, pharmacokinetics; TDI, time-dependent inhibitorCL, clearance; Drug–d
Keywords: سیتوکروم P450; Efavirenz; Isoniazid; Mitochondria; Complex I; Drug-induced liver injury (DILI); Hepatotoxicity; Methylene blue; Peroxynitrite1-ABT, 1-aminobenzotriazole; BNPP, bis-p-nitrophenyl phosphate; CBA, coumarin-7-boronic acid; CYP, cytochrome P450; EFV, efaviren
Keywords: سیتوکروم P450; Cell-based assay; Drug-induced liver injury; Drug metabolism; Immune reaction; InflammationALT, alanine aminotransferase; AMP, ampicillin; APAP, acetaminophen; AST, aspartate aminotransferase; CXCL1, chemokine (C-X-C motif) ligand 1; CYP, Cytochrome P450;
Keywords: سیتوکروم P450; AhR, aryl hydrocarbon receptor; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3-related protein; B[a]P, benzo[a]pyrene; B[a]Peq, B[a]P-equivalent; Chk1, checkpoint kinase 1; CT, coal tar; CYP, cytochrome P450; DE, diol epoxide; DNA
Keywords: سیتوکروم P450; BPA, Bisphenol A; SF-1, steroidogenic factor-1; ACTH, Adrenocorticotropic hormone; StAR, steroidogenic acute regulatory protein; CYP, cytochrome P450; 3β-HSD, 3β-hydroxysteroid dehydrogenase; NOAEL, no observed adverse effect level; 17β-HSD, 17β-hydroxyst
Keywords: سیتوکروم P450; Carbamazepine; Carbamazepine-10,11-epoxide; Delivery; Therapeutic drug monitoring; Drug–drug interaction; EpilepsyAEDs, antiepileptic drugs; CBZ, carbamazepine; Cl, clearance; CLZ, clonazepam; CYP, cytochrome P450; EURAP, European and International Regist
Keywords: سیتوکروم P450; amu, atomic mass unit; AUC, area under the curve; CL, plasma clearance; Cmax, peak plasma concentration; CYP, cytochrome P450; FDA, Food and Drug Administration; FEMA, Flavour and Extract Manufacturers Association of the United States; FL-no, FLAVIS numbe
Keywords: سیتوکروم P450; AUC, area under the curve; CL, plasma clearance; Cmax, peak plasma concentration; CYP, cytochrome P450; FDA, Food and Drug Administration; FEMA, Flavour and Extract Manufacturers Association of the United States; GLP, Good Laboratory Practices; GMP, good
Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK
Keywords: سیتوکروم P450; Ar, aryl; ATP, Adenosine-5′-triphosphate; AUC, area under the curve; BA, bioavailability; CYP, Cytochrome P450; DBU, 1,8-diazabicyclo[5.4.0]undec-7-ene; DCM, dichloromethane; DIPEA, diisopropylethylamine; Δ, heat; DME, 1,2-dimethoxyethane; DMF, N,N-dimeth
Pharmacokinetics and tissue distribution of 5,7-dimethoxyflavone in mice following single dose oral administration
Keywords: سیتوکروم P450; 5,7-DMF, 5,7-Dimethoxyflavone; PK, pharmacokinetic; LC–MS/MS, Liquid chromatography–tandem mass spectrometry; CYP, Cytochrome P450; P-gp, P-glycoprotein; MRP, multidrug resistance associated-proteins; BCRP, Breast Cancer Resistance Protein; MDR, multidrug
Toxicological responses following short-term exposure through gavage feeding or water-borne exposure to Dechlorane Plus in zebrafish (Danio rerio)
Keywords: سیتوکروم P450; Dechlorane Plus; Flame retardant; Endocrine disruption; Oxidative stress; Danio reriocat, catalase; crh, corticotropin releasing hormone; cyp, cytochrome P450; dio, deiodinase; DP, Dechlorane Plus; er, estrogen receptor; fsh, follicle stimulating hormone;
Calcitriol inhibits tumor necrosis factor alpha and macrophage inflammatory protein-2 during lipopolysaccharide-induced acute lung injury in mice
Keywords: سیتوکروم P450; ARDS, acute respiratory distress syndrome; CYP, cytochrome P450; ELISA, enzyme linked immunosorbent assay; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; MIP-2, macrophage inflammatory protein-2; NF-κB, nuclear factor kappa B; TLR, toll-
What causes the difference in synergistic potentials of propiconazole and prochloraz toward pyrethroids in Daphnia magna?
Keywords: سیتوکروم P450; CYP, cytochrome P450; DT95, disappearance time for 95% of the chemical; ECOD, 7-ethoxycoumarin-O-dealkylation; GC–ECD, gas chromatography–electron capture detection; ISO, International Organization for Standardization; OECD, Organisation for Economic Co-o
The reverse role of the hypothalamic paraventricular (PVN) and arcuate (ARC) nuclei in the central serotonergic regulation of the liver cytochrome P450 isoform CYP2C11
Keywords: سیتوکروم P450; ARC, arcuate nucleus; PVN, paraventrucular nucleus; CYP, cytochrome P450; HPLC, high performance liquid chromatography; 5-HT, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid; 5,7-DHT, 5,7-dihydroxytryptamine; 5-HTP, 5-hydroxytryptophan; DA, dopamine; DOPAC,
Knockdown of a putative insulin-like peptide gene LdILP2 in Leptinotarsa decemlineata by RNA interference impairs pupation and adult emergence
Keywords: سیتوکروم P450; JH, juvenile hormone; JHAMT, juvenile hormone acid methyltransferase; 20E, 20-hydroxyecdysone; IIS, insulin/insulin-like growth factor signaling pathway; RNAi, RNA interference; dsRNA, double-stranded RNA; ANOVA, analysis of variance; CYP, cytochrome P450
Dual strategies to improve oral bioavailability of oleanolic acid: Enhancing water-solubility, permeability and inhibiting cytochrome P450 isozymes
Keywords: سیتوکروم P450; OA, oleanolic acid; OPC, OA–phospholipid complex; HA, hydroxyapatite; OPCH, OA–phospholipid complex and hydroxyapatite; KCZ, ketoconazole; CYP, cytochrome P450; GI, gastrointestinal; PC, phospholipid; DDS, drug delivery system; SD, Sprague–Dawley; DSC, di
Cytochrome P450 genes in coronary artery diseases: Codon usage analysis reveals genomic GC adaptation
Keywords: سیتوکروم P450; CAD, Coronary artery disease; CVD, Cardiovascular diseases; CYP, Cytochrome P450; CUB, Codon usage bias; CAI, Codon adaptation index; Nc, Effective number of codon; RSCU, Relative synonymous codon usage; PCA, Principle component analysis; SCUO, Synonymous
Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms
Keywords: سیتوکروم P450; 3β-HSD, 3beta-hydroxysteroid dehydrogenase; 17β-HSD, 17beta-hydroxysteroid dehydrogenase; cGnRH, chicken gonadotropin-releasing hormone; CYP, cytochrome P450; E2, 17β-estradiol; ELISA, enzyme-linked immunosorbent assay; ERs, estrogen receptors; FSH, folli
Coordinate regulation of Cyp2e1 by β-catenin- and hepatocyte nuclear factor 1α-dependent signaling
Keywords: سیتوکروم P450; AHR, aryl hydrocarbon receptor; ChIP, chromatin immunoprecipitation; CMV, cytomegaly virus; CYP, cytochrome P450; GS, glutamine synthetase; HNF, hepatocyte nuclear factor; HNF1-RE, hepatocyte nuclear factor 1α response element; IP, immunoprecipitation; KO
Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner.
Keywords: سیتوکروم P450; B13/H, AR42J-B13/H cells; Cyp, Cytochrome P450; PB, phenobarbital; PROD, pentoxyresorufin-O-dealkylase; qRT-PCR, quantitative reverse transcription-PCR. BSA bovine serum albumin; Egf, epidermal growth factor; Erl., erlotinib; Veh, vehicle. DMSO dimethyl s
Pharmacokinetic study of isocorynoxeine metabolites mediated by cytochrome P450 enzymes in rat and human liver microsomes
Keywords: سیتوکروم P450; CN, corynoxeine; CYP, cytochrome P450; DCA, 18,19-dehydrocorynoxinic acid; DCAB, 18,19-dehydrocorynoxinic acid B; 22G-5-O-ICA, 5-oxoisocorynoxeinic acid-22-O-glucuronide; ICN, isocorynoxeine; 5-O-ICA, 5-oxoisocorynoxeinic acid; 17-O-de-16.17-di-5-O-IC, 17
CombiCap: A novel drug formulation for the basel phenotyping cocktail
Keywords: سیتوکروم P450; CYP, cytochrome P450; DDI, drug–drug interactions; BCS, biopharmaceutical classification system; CAF, caffeine; EFA, efavirenz; FLU, flurbiprofen; MET, metoprolol tartrate; MID, midazolam; OME, omeprazole; DMSO, dimethyl sulfoxide; SEM, scanning electron
PXR- and CAR-mediated herbal effect on human diseases
Keywords: سیتوکروم P450; ABC, ATP-binding cassette; AD, Alzheimer's disease; AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; CARKO, CAR-knockout; CGD, cholesterol gallstone disease; CPT1, carnitine palmitoyltransferase 1; CYP, cytochrome P450; DBD, DNA-bind
Resistant starch-rich wx/ae brown rice prevents insulin resistance and hypertriglyceridaemia in type 2 diabetic NSY mice
Keywords: سیتوکروم P450; wx/ae rice; Resistant starch; Insulin resistance; Hypertriglyceridaemia; Type 2 diabetesALT, alanine aminotransferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; CYP, cytochrome P450; DS, digestible starch; FAS, fatty acid synthase; FXR
The stress response of human proximal tubule cells to cadmium involves up-regulation of haemoxygenase 1 and metallothionein but not cytochrome P450 enzymes
Keywords: سیتوکروم P450; CYP, cytochrome P450; GGT, gamma glutamyl transpeptidase; 20-HETE, 20-hydroxyeicosatetraenoic acid; HO-1, heme oxygenase-1; MT1/2, metallothionein isoforms 1 and 2; PTC, proximal tubular epithelial cells; TNF-α, tumor necrosis factor-alphaCadmium; Cytochr
2-Acetyl-7-hydroxy-6-methoxy-1-methyl-1,2,3,4,-tetrahydroisoquinoline exhibits anti-inflammatory properties and protects the nigral dopaminergic neurons
Keywords: سیتوکروم P450; AMTIQ, 2-acetyl-7-hydroxy-6-methoxy-1-methyl-1,2,3,4,-tetarhydroisoquinoline; BH4, tetrahydrobiopterin; CYP, cytochrome P450; DAergic, dopaminergic; ELISA, enzyme-linked immuno sorbent assay; GTPCH, GTP cyclohydrolase I, IL-1β, interleukin-1β; iNOS, induc
Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450
Keywords: سیتوکروم P450; CYP, cytochrome P450; POR, NADPH-P450 oxidoreductase; HPLC, high performance liquid chromatography; 5-HT, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HTP, 5-hydroxytryptophan; DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic; HVA, homovanillic acid; NA
Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
Keywords: سیتوکروم P450; ADME, absorption, distribution, metabolism, excretion; CAR, constitutive androstane receptor (NR1I3); CITCO, 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; CYP, cytochrome P450; DMET, drug metabolism and transpor