کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052437 | 1074230 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax](/preview/png/2052437.png)
چکیده انگلیسی
This paper explores the relationship between Bax and the mitochondrial permeability transition pore (PTP). Isolated human colon tumor (HCT116) Bax− mitochondria exposed to recombinant Bax exhibited a slow, cyclosporin A-sensitive swelling, but only at [Bax] > 200 nM. The amount of Bax incorporated was much higher than that found in organelles isolated from HCT116 Bax+ staurosporine- or etoposide-treated apoptotic cells, casting doubts on the significance of the putative PT induction for apoptosis. Bax did not influence the electrophysiological properties of an approximately 1 nS channel ascribed to the Ca2+-dependent mitochondrial permeability transition pore. These observations indicate that the PTP is independent of Bax.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3695–3700
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3695–3700
نویسندگان
Silvia Campello, Umberto De Marchi, Ildikò Szabò, Francesco Tombola, Jean-Claude Martinou, Mario Zoratti,