Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect
Keywords: PTP، نفوذ پذیری انتقال منافذ; AD, Alzheimer's disease; T2DM, type 2 diabetes mellitus; APP, amyloid precursor protein; Aβ, amyloid-β peptide; CTF-b, C-terminal fragment beta; ROS, reactive oxygen species; HKII, Hexokinase-II; PTP, permeability transition pore; NF-κB, nuclear factor ka