کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052460 | 1074230 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress](/preview/png/2052460.png)
چکیده انگلیسی
Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock proteins in response to various types of stress. Although HSF1 activity is regulated by its post-translational modifications, alterations in mRNA expression have also been suggested. We here identified three new alternatively spliced isoforms of Drosophila HSF (dHSF) mRNA, named dHSFb, dHSFc, and dHSFd. We found that the ratio of dHSFb increases upon heat exposure, while that of dHSFd increases upon cold exposure. The dHSFc and dHSFd isoforms showed greater transcriptional activity than the other isoforms. Our findings suggest that alternative splicing regulates the transcriptional activity of dHSF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3842–3848
Journal: FEBS Letters - Volume 579, Issue 17, 4 July 2005, Pages 3842–3848
نویسندگان
Nobuhiro Fujikake, Yoshitaka Nagai, H. Akiko Popiel, Hiroki Kano, Masamitsu Yamaguchi, Tatsushi Toda,