کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052558 | 1074233 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1 AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1](/preview/png/2052558.png)
چکیده انگلیسی
Aluminum fluoride (AlFx) is known to activate directly the α subunit of G-proteins but not the homologous small GTP-binding proteins. However, AlFx can stabilize complexes formed between Ras, RhoA or Cdc42 and their corresponding GTPase-activating proteins (GAPs). Here, we demonstrate that Arf1GDP can be converted into an active conformation by AlFx to form a complex with the Arf-GAP ASAP1 in vitro and in vivo. Within this complex ASAP1, which GAP activity is inoperative, can still alter the recruitment of paxillin to the focal complexes, thus indicating that ASAP1 interferes with focal complexes independently of its GAP activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 25, 24 October 2005, Pages 5741–5745
Journal: FEBS Letters - Volume 579, Issue 25, 24 October 2005, Pages 5741–5745
نویسندگان
Stéphanie Klein, Michel Franco, Pierre Chardin, Frédéric Luton,