دانلود مقالات ISI درباره پروتئین فعال GTPase + ترجمه فارسی

اختلال در اتوفایگی و مسیرهای اندوسومالیزوسومی: نقش در پاتوژنز سندرم داون و بیماری آلزایمر

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease

Keywords: پروتئین فعال GTPase; AD; Alzheimer Disease; DS; Down Syndrome; Aβ; amyloid-β; HSA21; Chromosome 21; APP; Amyloid precursor protein; BACE1/2; β-site APP cleaving enzyme 1/2; βCTF; β carboxyl-terminal fragment; PSEN1; presenilin 1; APPL1; adaptor protein containing pleckst

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

تأثیر ناهمگونی در مسیر فسفونیوییدید 3-کیناز در سرطان های انسانی و درمان های احتمالی درمانی

The impact of heterogeneity in phosphoinositide 3-kinase pathway in human cancer and possible therapeutic treatments

Keywords: پروتئین فعال GTPase; PI3K; phosphatidylinositol 3-kinase; PIK3CA; PI3K catalytic subunit alpha; Akt; protein kinase B; mTOR; mammalian target of the rapamycin pathway; GPCRs; G-protein-coupled-receptors; PTEN; phosphatase and tensin homolog; GAP; GTPase-activating protein; pY

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

آیا داروهای مهار کننده مسیر مونولونات نیز سلول های بنیادی سرطانی را هدف قرار می دهند؟

Could drugs inhibiting the mevalonate pathway also target cancer stem cells?

Keywords: پروتئین فعال GTPase; Cancer stem-like cells; Mevalonate cascade; Ras; Rho; Stemness; Statins; Yap; ACAT; acetoacetyl-CoA transferase; acetyl-CoA; acetyl-coenzyme A; Arp2/3; actin-related protein 2/3 (actin polymerizing complex); BPs; bisphosphonates; CAMs; cell adhesion molec

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

اندستاتین و اندورپولین: یک روش معمول برای درمان آنفلوانزای سرطانی مشابه آنژیوتانس

Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers

Keywords: پروتئین فعال GTPase; PCD; programmed cell death; NC1; non-collagenous sequence 1; VEGFR1/2; vascular endothelial growth factor receptor 1/2; CAM; chick chorioallantoic membrane; MMPs; matrix metalloproteinases; GAP; GTPase-activating protein; FAK; focal adhesion kinase; MAPK;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

سیگنالینگ مضر در سرطان

Contextual signaling in cancer

Keywords: پروتئین فعال GTPase; AKT; protein kinase B; ATF4; activating transcription factor 4; cAMP; cyclic adenosine monophosphate; CCL5; (C-C motif) ligand 5; CNS; central nervous system; 4EBP1; 4E (elF4E) binding protein; ECM; extracellular matrix; ERK; p44/p42 extracellular signal-

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2016 سفارش ترجمه

ارکستر پروتئین های انتقال لیپید در تقاطع متابولیسم و ​​سیگنالینگ

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling

Keywords: پروتئین فعال GTPase; CERT; ceramide transfer protein; CETP; cholesteryl ester transfer protein; ER; endoplasmic reticulum; FABP; fatty acid-binding protein; FFAT; diphenylalanine in an acidic tract; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; GLs;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics

Keywords: پروتئین فعال GTPase; GEF; Guanine Exchange Factor; GAP; GTPase-activating protein; EGF; epidermal growth factor; PDGF; platelet-derived growth factor; EGFR; epidermal growth factor receptor; Pak; p21-activated kinase; EMT; epithelial to mesenchymal transition; SCC; squamous c

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI

Keywords: پروتئین فعال GTPase; AAV2; adeno-associated virus serotype-2; C2 (3, 4, 5, etc.); cervical spinal cord level 2 (3, 4, 5, etc.); CMAP; compound muscle action potential; CNS; central nervous system; CTB; cholera toxin subunit B; EMG; electromyography; GAP; GTPase-activating pro

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets

Keywords: پروتئین فعال GTPase; Platelet inhibition; Phosphoproteome; cGMP-dependent protein kinase/PKG; Small GTP-binding proteins; G proteins; NO; nitric oxide; PKA; protein kinase A; PKG; protein kinase G; PDE; phosphodiesterase; sGC; soluble guanylate cyclase; GPCR; G-protein couple

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Ca2+ signaling and Src-kinases-controlled cellular functions

Keywords: پروتئین فعال GTPase; Ca2+ channels; Cell signaling; Phosphatases; Receptors; Src-family kinases; A23187; 5-(methylamino)-2-({(2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl]-1,7-dioxaspiro[5.5]undec-2-yl}methyl)-1,3-benzoxazole-4-carboxyli

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

The Drosophila DOCK family protein Sponge is required for development of the air sac primordium

Keywords: پروتئین فعال GTPase; DOCK; dedicator of cytokinesis; Spg; Sponge; Mbc; Myoblast city; Zir; Zizimin-related; Ziz; Zizimin; GTPase; guanyl triphosphatase; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; GDI; guanine nucleotide dissociation inhibitor; SH

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

In situ detection of the activation of Rac1 and RalA small GTPases in mouse adipocytes by immunofluorescent microscopy following in vivo and ex vivo insulin stimulation

Keywords: پروتئین فعال GTPase; DMEM; Dulbecco's modified Eagle's medium; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; GST; glutathione S-transferase; HA; hemagglutinin; m-rac1-KO; muscle-specific rac1 knockout; Myr-p110α; myristoylated p110α; PBS; phosphat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleRas inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway

Keywords: پروتئین فعال GTPase; Metastasis; Ras; Ras inhibitors; LOX; PI3K; HIF-1α; CRC; colorectal cancer; LOX; lysyl oxidase; PI3K; phosphatidylinositol 3-kinase; HIF; hypoxia-inducible factor; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; ECM; extracellula

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex

Keywords: پروتئین فعال GTPase; Small G protein; Arf6; Arf GAP; ACAP3; Neuronal migration; ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains; Arf; ADP-ribosylation factor; ARNO; Arf nucleotide binding site opener; BCIP; 5-bromo-4-chloro-3-indolyl phosphate; BRAG2; Brefeldin A

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity

Keywords: پروتئین فعال GTPase; ARL15; ASAP2; PDPK1; AKT; Insulin resistance; Phosphorylation; ARL15; ADP-ribosylation factor-like GTPase 15; ARF; ADP-ribosylation factor; ASAP2; ARF-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; GEF; Guanine nucleotide-exchange fac

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

Keywords: پروتئین فعال GTPase; Liver Cancer; Mouse Model; CRISPR Screen; Tumor Suppressor Genes; GAP; GTPase-activating protein; HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; mRNA; messenger RNA; PCR; polymerase chain reaction; sgRNA; single-guide RNA; shRNA; s

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells

Keywords: پروتئین فعال GTPase; ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease

Keywords: پروتئین فعال GTPase; AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas

Keywords: پروتئین فعال GTPase; NF1; neurofibromatosis type 1; LGG; low grade glioma; MAPK; mitogen activated protein kinase; mTOR; mammalian target of rapamycin; PA; pilocytic astrocytoma; MPNST; malignant peripheral nerve sheath tumours; GAP; GTPase-activating protein; RB; retinoblast

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching

Keywords: پروتئین فعال GTPase; MD; molecular dynamics; HDX; hydrogen-deuterium exchange; MS; mass spectrometry; P-loop; phosphate-binding loop; GDP; guanosine diphosphate; GTP; guanosine triphosphate; GAP; GTPase-activating protein; SIIP; switch II pocket; GMPPNP; guanylyl imidodipho

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2 + signaling

Keywords: پروتئین فعال GTPase; a.a.; amino acid; ATP; adenosine triphosphate; BH domain; Bcl-2-homology domain; BI-1; Bax inhibitor-1; BIRD-2; Bcl-2/IP3R disruptor-2; BRCA1; breast and ovarian cancer susceptibility gene 1; [Ca2 +]cyt; cytosolic Ca2 + concentration; CLL; chronic lymph

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Autophagy machinery in the context of mammalian mitophagy

Keywords: پروتئین فعال GTPase; PINK1; PTEN-induced putative kinase 1; CCCP; carbonyl cyanide m-chlorophenylhydrazone; OMM; outer mitochondrial membrane; ATG; autophagy-related; ULK1; unc-51 like kinase 1; FIP200; focal adhesion kinase family interacting protein of 200 kDa; mTor; mecha

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

IQGAP1 in rectal adenocarcinomas: Localization and protein expression before and after radiochemotherapy

Keywords: پروتئین فعال GTPase; 5-FU; 5-fluorouracil; APC; adenomatous polyposis coli; AUC; area under curve; ERK; extracellular signal-regulated kinase; GAP; GTPase-activating protein; IQGAP1; IQ[isoleucine-glutamine domain]-guanosine triphosphatase activating protein 1; MAPK; mitogen-

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

RGS19 converts iron deprivation stress into a growth-inhibitory signal

Keywords: پروتئین فعال GTPase; Regulator of G-protein signaling; N-myc downstream-regulated gene 1 protein; Cysteine string motif; Iron-binding protein; AC; adenylyl cyclase; CCI; CREB-CBP binding inhibitor; CCK-8; cell counting kit-8; CREB; cAMP response element-binding protein; CSM;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling

Keywords: پروتئین فعال GTPase; 293 F; cell line of human embryonic kidney origin; 6× His; hexahistidine; aa; amino acids; AC; adenylyl cyclase; AR; adrenergic receptors; AT1; Angiotensin Receptor 1; CT; carboxyl terminus; ΔΝRGS4; RGS4 lacking its N-terminal domain; DAMGO; [d-Ala2,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Pseudogenization of sopA and sopE2 is functionally linked and contributes to virulence of Salmonella enterica serovar Typhi

Keywords: پروتئین فعال GTPase; sopASTm; S. Typhimurium sopA gene; ΨsopASTy; S. Typhi sopA pseudogene; sopE2STm; S. Typhimurium sopE2 gene; ΨsopE2STy; S. Typhi sopE2 pseudogene; GEF; Rho guanine nucleotide exchange factor; GAP; GTPase-activating protein; sopA; sopE2; Pseudogene; Host-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

EGF stimulates the activation of EGF receptors and the selective activation of major signaling pathways during mitosis

Keywords: پروتئین فعال GTPase; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; PLC-γ1; phospholipase C-γ1; PI3K; phosphoinositide 3-kinase; GAP; GTPase-activating protein; ERKs; extracellular signal-regulated kinases; MEK; mitogen-activated protein kinase kinase

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

Keywords: پروتئین فعال GTPase; Sesn; sestrin; ROS; reactive oxygen species; Prx; peroxiredoxin; Srx; sulfiredoxin; ERK; extracellular signal-regulated kinase; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; mTORC1; mechanistic target of ra

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

Redox regulation of Rac1 by thiol oxidation

Keywords: پروتئین فعال GTPase; ABD-f; 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole; βME; β-mercaptoethanol; CD; circular dichroism; DMEM; Dulbecco's modified Eagle׳s medium; DTPA; diethylenetriaminepentaacetic acid; DTT; dithiothreitol; EDTA; ethylenediaminetetraacetic acid; eN

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2015 سفارش ترجمه

The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages

Keywords: پروتئین فعال GTPase; 1,25(OH)2D3 or 1,25D; 1α,25-dihydroxyvitamin D3; ADAM17; ADAM metallopeptidase domain 17; Arf; ADP-ribosylation factor; ASAP2; Arf-GAP with SH3 domain, ankyrin repeat and PH domain 2; B2M; beta-2-microglobulin; ChIA-PET; chromatin interaction analysis wi

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Analysis of subcellular localization and function of the yeast Rab6 homologue, Ypt6p, using a novel amino-terminal tagging strategy

Keywords: پروتئین فعال GTPase; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; VPS; vacuolar protein sorting; GFP; green fluorescent protein; Ypt6p; Rab/Ypt; Vesicle transport; N-terminal tagging; Budding yeast;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

The guanine nucleotide exchange factor Tiam1: A Janus-faced molecule in cellular signaling

Keywords: پروتئین فعال GTPase; DH; Dbl homology; JIP/IB2; c-Jun N-terminal kinase-interacting protein/islet-brain 2; GAP; GTPase-activating protein; GDP; guanosine diphosphate; GDI; guanine dissociation inhibitor; GEF; guanine nucleotide-exchange factor; GTP; guanosine triphosphate; PH

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle

Keywords: پروتئین فعال GTPase; BSA; bovine serum albumin; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; GFP; green fluorescent protein; GST; glutathione S-transferase; HA; hemagglutinin; HSA; human skeletal actin; m-rac1-KO; muscle-specific rac1 knockout; Myr

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Keywords: پروتئین فعال GTPase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt substrate of 160 kDa; GAP; GTPase-activating protein; GLUT; glucose transporter; PAS; phospho-Akt substrate; PI 3-kinase; phosphoinositide 3-kinas

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

mTOR signaling in tumorigenesis

Keywords: پروتئین فعال GTPase; mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2014 سفارش ترجمه

RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK

Keywords: پروتئین فعال GTPase; FAK; focal adhesion kinase; IGF-I; insulin-like growth factor I; Erk; extracellular signal-regulated kinase; GAP; GTPase-activating protein; AGAP; Arf GAP with G protein-like domain (GLD), ankyrin repeat, and PH domain; PBS; phosphate-buffered saline; siR

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2014 سفارش ترجمه

POT1b regulates phagocytosis and NO production by modulating activity of the small GTPase Rab5

Keywords: پروتئین فعال GTPase; POT1b; protection of telomeres 1b; NO; nitric oxide; EEA1; early endosome antigen 1; NOS; nitric oxide synthase; iNOS; inducible NOS; PBS; phosphate-buffered saline; GFP; green fluorescence protein; IgG-HRP; immunoglobulin G-horseradish peroxidase; GAP; G

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

GRAB is a binding partner for the Rab11a and Rab11b GTPases

Keywords: پروتئین فعال GTPase; ERC; endosomal-recycling compartment; GAP; GTPase-activating protein; GEF; guanine nucleotide exchange factor; GRAB; guanine nucleotide exchange factor for Rab3A; InsP6K-1; inositol hexakisphosphate kinase-1; Rab3IL1; RAB3A interacting protein (rabin3)-li

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

p21-activated kinases and gastrointestinal cancer

Keywords: پروتئین فعال GTPase; AID; auto-inhibitory domain; CDK5RAP3; CDK5 kinase regulatory subunit-associated protein 3; CRC; colorectal carcinoma; EGFR; epithelial growth factor receptor; GAP; GTPase-activating protein; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis

Keywords: پروتئین فعال GTPase; BAR; Bin-Amphiphysin-Rvs; Bin; Bridging integrator; CSA; Cross-sectional area; DM; Differentiation media; eMyHC; Embryonic myosin heavy chain; F-actin; Filamentous actin; GAP; GTPase-activating protein; GEF; Guanine nucleotide exchange factor; GM; Growth

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase

Keywords: پروتئین فعال GTPase; ERC; endosomal-recycling compartment; FIP2; Rab11 family interacting protein 2; GAP; GTPase-activating protein; GDI; GTP/GDP dissociation inhibitor; GEF; guanine nucleotide exchange factor; GTP; guanosine 5′ triphosphate; ITC; isothermal titration calor

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Impaired lipid accumulation in the liver of Tsc2-heterozygous mice during liver regeneration

Keywords: پروتئین فعال GTPase; TSC; tuberous sclerosis; mTOR; mammalian target of rapamycin; GAP; GTPase-activating protein; MAPK; mitogen-activated protein kinase; p90 RSK; p90 ribosomal S6 kinase; ERK; extracellular signal-regulated kinase; P70S6K; p70 ribosomal S6 kinase; AMPK; 5′

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Crystal structures of the state 1 conformations of the GTP-bound H-Ras protein and its oncogenic G12V and Q61L mutants

Keywords: پروتئین فعال GTPase; GAP; GTPase-activating protein; GppNHp; guanosine 5′-(β,γ-imido)triphosphate; RBD; Ras-binding domain; WT; Wild type; rms; root mean square; Ras; Small GTPases; Oncogene; Crystal structure; Conformational dynamics;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells

Keywords: پروتئین فعال GTPase; NO; nitric oxide; cGK; cGMP-dependent protein kinase; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; 8-pCPT-cGMP; 8-(4-chlorophenylthio)-cGMP; RA; all-trans-retinoic acid; LPA; 1-oleoyl lysophosphatidic acid; VASP; vasodilator-st

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Research ReportActivation of Ras/MEK/ERK signaling in chronic subdural hematoma outer membranes

Keywords: پروتئین فعال GTPase; CSDH; chronic subdural hematoma; ERK; extracellular signal-regulated kinase; GAP; GTPase-activating protein; MEK; extracellular signal-regulated kinase kinase; VEGF; vascular endothelial growth factor; Chronic subdural hematoma; ERK; MEK; Ras;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin

Keywords: پروتئین فعال GTPase; ADHD; attention deficit hyperactivity disorder; ASD; autism spectrum disorders; GAP; GTPase-activating protein; TSC; tuberous sclerosis complex; TSC2-DN; TSC2-dominant/negative; Tuberous sclerosis complex; Autism; TSC2; GAP domain; mTORC1; Social interact

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex

Keywords: پروتئین فعال GTPase; 4E-BP; eIF4E binding protein; ACSF; artificial cerebrospinal fluid; CMV; cytomegalovirus; FXS; fragile X syndrome; GAP; GTPase-activating protein; GDP; guanosine diphosphate; GTP; guanosine triphosphate; mTORC1; mammalian target of rapamycin complex 1; Rh

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners

Keywords: پروتئین فعال GTPase; AMPK; AMP-activated protein kinase; ARF; ADP-ribosylation factor; CDK5; cyclin-dependent kinase 5; CEM; caveolin-enriched membrane; CRMP-2; collapsin response mediator protein-2; EGF; epidermal growth factor; EGFR; EGF receptor; GAP; GTPase-activating pro

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and structural basis for a novel interaction between Vav2 and Arap3

Keywords: پروتئین فعال GTPase; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; SH2; Src homology 2; pY; phosphotyrosine; PV; pervanadate; MD; molecular dynamics; Vav2; Arap3; SH2 domain; NMR; Protein-peptide interaction; Complex structure;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes

Keywords: پروتئین فعال GTPase; BAPTA-AM; 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis acetoxymethyl ester; GAP; GTPase-activating protein; GIRK; G-protein coupled inward rectifier K+ channel; GPCR; G protein-coupled receptor; RGS; regulator of G protein signali

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه