کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10932055 | 1093685 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis
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کلمات کلیدی
PAKp21-activated protein kinaseDifferentiation mediaMyogenesisGEFCDC42Rac1F-actinfilamentous actin - actin filamentousCSA - ایالات مؤتلفهٔ آمریکاBAR - بارMuscle regeneration - بازسازی عضلاتBIN - باینDomain - دامنهBAR domain - دامنه BARGrowth media - رسانه های رشدGAP - شکافguanine nucleotide exchange factor - فاکتور تبادل نوکلئوتید گوانینcross-sectional area - مقطع عرضیknockout - ناکاوتwild-type - نوع وحشیRetrovirus - ویروس پسگرد یا رتروویروسGTPase-activating protein - پروتئین فعال GTPase
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Actin dynamics are necessary at multiple steps in the formation of multinucleated muscle cells. BAR domain proteins can regulate actin dynamics in several cell types, but have been little studied in skeletal muscle. Here, we identify novel functions for the N-BAR domain protein, Bridging integrator 3 (Bin3), during myogenesis in mice. Bin3 plays an important role in regulating myofiber size in vitro and in vivo. During early myogenesis, Bin3 promotes migration of differentiated muscle cells, where it colocalizes with F-actin in lamellipodia. In addition, Bin3 forms a complex with Rac1 and Cdc42, Rho GTPases involved in actin polymerization, which are known to be essential for myotube formation. Importantly, a Bin3-dependent pathway is a major regulator of Rac1 and Cdc42 activity in differentiated muscle cells. Overall, these data classify N-BAR domain proteins as novel regulators of actin-dependent processes in myogenesis, and further implicate BAR domain proteins in muscle growth and repair.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 382, Issue 1, 1 October 2013, Pages 160-171
Journal: Developmental Biology - Volume 382, Issue 1, 1 October 2013, Pages 160-171
نویسندگان
Adriana Simionescu-Bankston, Giovanna Leoni, Yanru Wang, Peter P. Pham, Arivudainambi Ramalingam, James B. DuHadaway, Victor Faundez, Asma Nusrat, George C. Prendergast, Grace K. Pavlath,