Keywords: Actin dynamics; Rho GTPases; dendritic spines; postsynapse; Abi-1; Abelson interacting protein 1; Abp1; actin binding protein 1; ACTN4; α-actinin-4; ADF; actin-depolymerizing factor; ADHD; attention deficit/hyperactivity disorder; ADNP; activity-dependen
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Keywords: Phosphatidic acid; Diacylglycerol kinase; Phospholipase D; Membrane; Stress response; Hormonal regulation; ABA; abscisic acid; DGPP; diacylglycerol pyrophosphate; flg22; flagellin peptide; Gly3P; glycerol-3-phosphate; IAA; indol-3-acetic acid; LPP; lipid-
Keywords: Di-n-butyl phthalate (DBP); Neuroplasticity; Rho-GTPase; ANOVA; analysis of variance; BBP; benzyl butyl phthalate; CREB; cyclic adenosine monophosphate response element binding protein; DBP; di-n-butyl phthalate; DiBP; diisobutyl phthalate; DEHP; di(2-eth
Evaluation of inflammation-related signaling events covering phosphorylation and nuclear translocation of proteins based on mass spectrometry data
Keywords: Dex; dexamethasone; FDR; false discovery rate; IL; interleukin; JUN; transcription factor AP-1; LFQ; label-free quantification; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; NFκB; nuclear factor 'kappa-light-chain-enhancer' of acti
Label-free quantitative phosphoproteomic profiling of cellular response induced by an insect cytokine paralytic peptide
Keywords: PP; Paralytic peptide; LC-MS/MS; liquid chromatography-tandem mass spectrometry; TFs; transcription factors; PKs; protein kinases; KEGG; Kyoto Encyclopedia of Genes and Genomes; MAPK; mitogen-activated protein kinase; PAK; p21-activated kinase; GBP; growt
Keywords: AP-1; activator protein 1; APC; antigen-presenting cells; ARE; AU-rich element; ASK; Apoptosis Signal regulating Kinase; ATF-2; Activating Transcription Factor 2; CRE; Cyclic AMP Responsive Element; CBP; CREB binding protein; CsA; ciclosporin A; ERK; Extr
Keywords: Dendritic spine; Synaptic plasticity; Neurodegenerative diseases; Psychiatric disorders; Glutamate receptor; Calcium signaling; ADHD; attention deficit hypersensitive disorders; FXS; Fragile X-syndrome; CNS; central nervous system; GABA; gamma amino butyr
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics
Keywords: GEF; Guanine Exchange Factor; GAP; GTPase-activating protein; EGF; epidermal growth factor; PDGF; platelet-derived growth factor; EGFR; epidermal growth factor receptor; Pak; p21-activated kinase; EMT; epithelial to mesenchymal transition; SCC; squamous c
Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration
Keywords: Wnt5b; Wnt10a; TAX1BP3; CDC42; Rhotekin; β-Catenin; ARHGEF; rhoA guanine nucleotide exchange factor; CDC42; cell division cycle 42; CNS; central nervous system; daam1; disheveled-associated activator of morphogenesis 1; DAPI; 4â²,6-diamidino-2-phenylind
Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells
Keywords: Abl; ableson kinase; ABR; actin binding repeat; Arg; ableson related gene kinase; Arp2/3; actin related protein 2/3; ATAT1; alpha-tubulin N-acetyltransferase 1; DMEM; Dulbecco's modified Eagle's medium; DOX; doxycycline; Erk; extracellular signal-re
Tubulin-dependent secretion of S100A6 and cellular signaling pathways activated by S100A6-integrin β1 interaction
Keywords: BSA; bovine serum albumin; CCCP; carbonyl cyanide chlorophenylhydrazone; DPBS; Dulbecco's Phosphate Buffered Saline; DTT; dithiothreitol; EGFR; epidermal growth factor receptor; FAK; focal adhesion kinase; GSK3β; glycogen synthase kinase-3β; ILK; integr
Functions and dysfunctions of Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) and CaMKP-N/PPM1E
Keywords: Binding protein; Cell signaling; Disorder; Metastasis; microRNA; Negative regulation; Aβ; amyloid β; AD; Alzheimer's disease; AMPK; AMP-activated protein kinase; CaMK; Ca2+/calmodulin-dependent protein kinase; CaMKP; Ca2+/calmodulin-dependent protein ki
EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function
Keywords: βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Keywords: ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMT; amoeboid-mesenchymal transition; APC; adenomatosis polyposis coli; Arp2/3; actin related protein 2/3; Cdc42; cell division control protein 42 homolog; CK1; casein kinase 1; COX-2; cyclooxygena
p21-activated kinase 4 regulates HIF-1α translation in cancer cells
Keywords: Pak4; HIF-1α; Hypoxia; Akt; mTOR; 4E-BP1; Pak; p21-activated kinase; HIF; hypoxia-inducible factor; PHD; prolyl hydroxylase domain-containing protein; FBS; fetal bovine serum; HRE; hypoxia response element; PGK-1; phosphoglycerate kinase-1; DFO; desferri
Regulation of merlin by protein phosphatase 1-TIMAP and EBP50 in endothelial cells
Keywords: BPAEC; Bovine Pulmonary Artery Endothelial Cells; ERM; ezrin, radixin, moesin; FERM; band 4.1, ezrin, radixin, moesin; GST; glutathione S-transferase; ILK; integrin-linked kinase; IP; immunoprecipitation; MYPT; myosin phosphatase target subunit; NF2; neur
Anti-inflammatory effects of Shufengjiedu capsule for upper respiratory infection via the ERK pathway
Keywords: SFJD; Shufengjiedu capsule; RNA; Seq RNA sequence; PAK; Pseudomonas aeruginosa; KEGG; Kyoto Encyclopedia of Genes and Genomes; UPLC/Q-TOF-MS; ultra-performance liquid chromatography quadrupole/time of flight mass spectrometry; ARUSC; Antibiotic Resistance
Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway
Keywords: MUC1; Membrane-tethered mucin; Macrophage; Inflammation; Pseudomonas aeruginosa; aa; amino acid; AEC; airway epithelial cell; AM; alveolar macrophage; CF7; control peptide 7; EGFR; epidermal growth factor receptor; ERK1/2; extracellular signal-regulated k
Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration
Keywords: AAV(s); adeno-associated virus(es); ADAM; a disintegrin and metalloprotease; AGO(2); argonaut (2); AKT; protein kinase B; APC; adenomatous polyposis coli; ASO(s); antisense oligonucleotide(s); ATF3; activating transcription factor 3; BBB; blood brain barr
Structure, biochemistry, and biology of PAK kinases
Keywords: PAK; p21-activated kinase; AID; auto-inhibitory domain; PBD; p21-binding domain; p21-Activated kinase; PAK; Cytoskeleton remodeling; Cancer; Nervous system; Heart;
Regulation of HC11 mouse breast epithelial cell differentiation by the E-cadherin/Rac axis
Keywords: cRac1; Cellular Rac1; CRIB; Cdc42/Rac-interactive binding; E-cadherin; Epithelial cadherin; ECL; enhanced chemiluminescence; EGF; Epidermal growth factor; GAP; GTPase activating protein; GDP; guanosine 5â²-diphosphate; GEF; guanine nucleotide exchange fa
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation
Keywords: Cys; cysteine; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; GPCR; G protein-coupled receptor; HEK 293; human embryonic kidney 293; HPK1; hematopoietic progenitor kinase 1; MST; mammalian Ste20 kinase; MAP4K; MAP kinase
Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model
Keywords: SBI; surgical brain injury; Robo1; roundabout1; CD45; cluster of differentiation 45; MPO; myeloperoxidase; srGAP1; Slit-Robo GTPase activating protein 1; ELISA; enzyme linked immunosorbent assay; ICV; intracerebroventricular; PBS; phosphate buffered salin
Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression
Keywords: ANCOVA; analysis of covariance; PAK; p21-activated kinase; PFC; prefrontal cortex; PMI; postmortem interval; qPCR; quantitative polymerase chain reaction; RT; reverse transcription; postmortem; mRNA expression; coexpression analysis; p21-activated kinase;
The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis events
Keywords: CCK; COOH-terminal octapeptide of cholecystokinin; TPA; 12-O-tetradecanoylphorbol-13-acetate; PAK; p21-activated kinases; SFK; Src family of kinases; PKC; protein kinase C; PYK2; proline-rich tyrosine kinase 2; FAK; focal adhesion kinase; SHC; Src homolog
Steroid maintenance is associated with an increased risk of infections but has no effect on patient and graft survival in pancreas transplantation: A retrospective review of the UNOS database
Keywords: Graft; Immunosuppression; Induction; Maintenance; Outcome; Steroids; BMI; body mass index; CSM; chronic steroid maintenance; DCD; donors after cardiac death; ESW; early steroid withdrawal; PAK; pancreas after kidney; PTA; pancreas transplant alone; PWK; p
Sec8 regulates cytokeratin8 phosphorylation and cell migration by controlling the ERK and p38 MAPK signalling pathways
Keywords: IF; intermediate filament; MAPKs; mitogen-activated protein kinases; MAP2K; MAPK kinase; MAP3K; MAPK kinase kinase; ERK; extracellular signal-regulated kinase; JNK; c-jun N-terminal kinase; KSR; kinase suppressor of Ras; MEK1/2; ERK kinase 1/2; JIP4; JNK-
CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1
Keywords: CDK5; cyclin-dependent kinase; GLU; glutamate; AD; Alzheimer's disease; DIV; day in vitro; ROS; reactive oxygen species; BDNF; brain-derived neurotrophic factor; ROCK; Rho kinase; LDH; lactate dehydrogenase; G-LISA; GTP enzyme-linked immunosorbent assay;
Regulation of hippocampal synaptic plasticity by BDNF
Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n
Inner gray halo, a novel dermoscopic feature for the diagnosis of pigmented actinic keratosis: Clues for the differential diagnosis with lentigo maligna
Keywords: confocal; dermoscopy; face; histopathology; lentigo maligna; pigmented actinic keratosis; CI; confidence interval; IGH; inner gray halo; LM; lentigo maligna; PAK; pigmented actinic keratosis; RCM; reflectance confocal microscopy;
BDNF mechanisms in late LTP formation: A synthesis and breakdown
Keywords: Brain-derived neurotrophic factor (BDNF); TrkB signaling; Synaptic plasticity; Long-term potentiation (LTP); Protein synthesis; Translation control; Cytoskeletal dynamics; Arc; activity-regulated cytoskeleton-associated protein; AS; Angelman syndrome; AS-
BDNF-induced local protein synthesis and synaptic plasticity
Keywords: Brain-derived neurotrophic factor (BDNF); Synaptic plasticity; Long-term potentiation (LTP); Translation; RNA transport; ADF; actin-depolymerizing factor; A2RE; heterogeneous nuclear ribonucleoprotein (hnRNP) A2 response element; Arc; activity-regulated c
Syndecan 4 regulation of PDK1-dependent Akt activation
Keywords: S4; syndecan 4; PI3K; phosphatidylinositol 3 kinase; myrPKCα; myristoylated protein kinase C; PAK; p21 protein (CDC42/Rac)-activated kinase; Syndecan; PKC; AKT; Angiogenesis;
p21-activated kinases and gastrointestinal cancer
Keywords: AID; auto-inhibitory domain; CDK5RAP3; CDK5 kinase regulatory subunit-associated protein 3; CRC; colorectal carcinoma; EGFR; epithelial growth factor receptor; GAP; GTPase-activating protein; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular
Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells
Keywords: HCC; hepatocellular carcinoma; Mst; mammalian sterile 20-like kinase; Stk; sterile 20-like kinase; PAK; p21 activated kinase; RASSF; RAS Association domain family; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; PARP; poly ADP-ribose polymerase; FL; ful
PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively
Keywords: ECM; extracellular matrix; EGF; epidermal growth factor; FGF; fibroblast growth factor; GEF; guanine nucleotide exchange factor; HGF; hepatocyte growth factor; MMP; matrix metalloproteinase; PAK; p21-activated kinase; PI3K; phosphoinositide 3-kinase; PTEN
The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis
Keywords: BAR; Bin-Amphiphysin-Rvs; Bin; Bridging integrator; CSA; Cross-sectional area; DM; Differentiation media; eMyHC; Embryonic myosin heavy chain; F-actin; Filamentous actin; GAP; GTPase-activating protein; GEF; Guanine nucleotide exchange factor; GM; Growth
The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity
Keywords: 5-FU; 5-fluorouracil; BrdU; 5-bromo-2â²-deoxyuridine; FACS; fluorescence activated cell sorting; FAK; focal adhesion kinase; GMP; granulocyte-monocyte progenitor; HPC; hematopoietic progenitor cell; KLS; c-Kit+lineageâSca-1+; LT-HSC; long-term hemato
LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4
Keywords: F-actin; filamentous actin; G-actin; globular actin; LIMK; LIM domain kinase; LRRK2; leucine-rich repeat kinase 2; PAK; p21 protein (Cdc42/Rac)-activated kinase; qRT-PCR; quantitative reverse transcription polymerase chain reaction; GEF; guanine nucleotid
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells
Keywords: Ras; extracellular signal-regulated kinase; PAK; Bam32; Sos; phospholipase C-γ1
Dendritic spine plasticity as an underlying mechanism of neuropathic pain: Commentary on Tan et al.
Keywords: AMPA; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; aPKC; atypical protein kinase C; BDNF; brain derived neurotrophic factor; CCI; chronic constriction injury; DHPG; dihydroxyphenyglycine; FMRP; fragile X mental retardation protein; IL-6; inte
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis
Keywords: GPCR; G protein-coupled receptor; GRK; GPCR kinase; GIT; GRK-interacting protein; ARF-GAPs; ADP-ribosylation factor GTPase-activating proteins; GEF; guanine nucleotide exchange factor; MSC; mesenchymal stem cell; qCT; quantitative micro-computed tomograph
Vav1 in differentiation of tumoral promyelocytes
Keywords: GEF; guanosine exchange factor; APL; acute promyelocytic leukemia; ATRA; All-trans retinoic acid; LIC; leukemia initiating cells; PMA; phorbol 12-myristate 13-acetate; PIP; phosphatidylinositol 4-phosphate; PIP2; phosphatidylinositol 4, 5-bisphosphate; PI
Small GTPases Rap1 and RhoA regulate superoxide formation by Rac1 GTPases activation during the phagocytosis of IgG-opsonized zymosans in macrophages
Keywords: DHE; dihydroethidium; DMEM; Dulbecco's modified Eagle medium; Epac; exchange protein directly activated by cAMP; ERK; extracellular signal-regulated kinases; FBS; fetal bovine serum; FITC; fluorescein isothiocyanate; GAP; GTPase activating proteins; GDI;
The PDZ-binding motif of MCC is phosphorylated at position â 1 and controls lamellipodia formation in colon epithelial cells
Keywords: MCC; mutated in colorectal cancer; PDZ; post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (DlgA), or Zonula occludens-1 protein (zo-1); PAK; p21 activated kinase; MCC; Lamellipodia; Scrib; PDZ; PDZ-binding motif; Myosin-IIB;
Molecular Pathogenesis of Vestibular Schwannomas: Insights for the Development of Novel Medical Therapies
Keywords: osÅoniak przedsionkowy; neurofibromatoza typ 2; NF2; AKT; EGFR; PDGF; VEGF; merlina; Vestibular Schwannoma; Neurofibromatosis type 2; NF2; AKT; EGFR; PDGF; VEGF; PAK; Merlin;
Proteins implicated in the increase of adhesivity induced by suberoylanilide hydroxamic acid in leukemic cells
Keywords: SAHA; Adhesion; Cofilin; Vimentin; PAK; HDAC inhibitor
Hepatitis B Virus X Protein Confers Resistance of Hepatoma Cells to Anoikis by Up-regulating and Activating p21-Activated Kinase 1
Keywords: Liver Cancer; Mouse Model; Metastasis; Apoptosis Signal Transduction; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; Mcl1; myeloid cell leukemia sequence 1; PAK; p21-activated kinase; PI; propidium iodide; PVTT; p