کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8288762 | 1536265 | 2018 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functions and dysfunctions of Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F) and CaMKP-N/PPM1E
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کلمات کلیدی
AMPKp21-activated protein kinaseTGCTCaMKPMUPPCDHPAKCaMKTACGAPDHAβ4-methylumbelliferyl phosphate - 4-methylumbelliferyl فسفاتAMP-activated protein kinase - AMP-پروتئین کیناز فعال شده استKAP - CAPHCC - HCCMAPK - MAPKamyloid β - آمیلوئید βDisorder - اختلال Alzheimer's disease - بیماری آلزایمرtransverse aortic constriction - تنگی عرضی آئورتTesticular germ cell cancer - سرطان سلول ژنتیکی مثبتCell signaling - سیگنالینگ سلولیMetastasis - متاستاز Genome-wide association studies - مطالعات مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومNegative regulation - مقررات منفیMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAbinding protein - پروتئین متصلmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenCa2+/calmodulin-dependent protein kinase - پروتئین کیناز وابسته به کلسیم و پتاسیم Ca2 + /protocadherin - پروتکلادیرینSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدHepatocellular carcinoma - کارسینوم هپاتوسلولار(کارسینوم سلولهای استخوانی)glyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Intracellular signal transduction is built on the basis of the subtle balance between phosphorylation and dephosphorylation. Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP/PPM1F/POPX2) and CaMKP-N (PPM1E/POPX1) are Ser/Thr phosphatases that belong to the PPM (protein phosphatase, Mg2+/Mn2+-dependent) family. The former was discovered in rat brain as a novel protein phosphatase regulating Ca2+/calmodulin-dependent protein kinases (CaMKs), whereas the latter was first identified in human cDNA databases using the rat CaMKP sequence. Subsequent studies have revealed that they are involved in various cellular functions through regulation of not only CaMKs but also other protein kinases such as AMP-activated protein kinase. Furthermore, accumulating evidence shows possible involvement of CaMKP and CaMKP-N in the pathogenesis of various diseases including cancer. Therefore, the biochemistry of CaMKP and CaMKP-N largely contributes to molecular medicine targeting these phosphatases. In this review, we summarized recent progress in the enzymology and biology of CaMKP and CaMKP-N. We also focused on etiology studies in which CaMKP and CaMKP-N are involved. Based on the emerging evidence, future perspectives of studies on these phosphatases and related issues to be elucidated are discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Biochemistry and Biophysics - Volume 640, 15 February 2018, Pages 83-92
Journal: Archives of Biochemistry and Biophysics - Volume 640, 15 February 2018, Pages 83-92
نویسندگان
Atsuhiko Ishida, Noriyuki Sueyoshi, Isamu Kameshita,