کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052567 1074233 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osmotic regulation of STAT3 stability in H4IIE rat hepatoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Osmotic regulation of STAT3 stability in H4IIE rat hepatoma cells
چکیده انگلیسی

Little is known about the regulation of signal transducer and activator of transcription (STAT) stability. Here the osmolarity-dependence of STAT3 stability, ubiquitination, Tyr705 phosphorylation, STAT3 transactivation and γ-fibrinogen (γ-FBG) expression was studied in hepatoma cells. Hyper-osmolarity accelerated STAT3 degradation which was prevented by proteasome inhibitors. Hypo-osmolarity stabilized STAT3, most likely due to a decrease in STAT3 ubiquitination. Accordingly, STAT3 Tyr705 phosphorylation, α2-macroglobulin promoter activity and γ-FBG expression were osmosensitive. Modulation of STAT3 stability may contribute to a hydration dependence of acute phase protein expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 25, 24 October 2005, Pages 5791–5797
نویسندگان
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