Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Angiogenesis; Chronic subdural hematoma; STAT3CSDH, Chronic subdural hematoma; IL-6, Interleukin-6; JAK, Janus kinase; STAT, Signal transducer and activator of transcription; STAT3, Signal transducer and activator of transcription 3; VEGF, Vascular endoth
مقالات ISI STAT، مبدل سیگنال و فعال کننده رونویسی (ترجمه نشده)
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Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; BPH, benign prostate hyperplasia; CK, cytokeratin; Erk1/2, extracellular signal-regulated kinase 1/2; Lin, lineage; MTT, thiazolyl blue tetrazolium bromide; Stat, signal transducer and activator of transcription; Sca-1, stem cell antigen 1; Trop2, tumor-a
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IL-6, interleukin-6; JAK, Janus kinase; STAT, signal transducer and activator of transcription; PI3K, phosphoinositide 3-kinase; RA, rheumatoid arthritis; Th, T-helper; TNFα, tumor necrosis factor α; IFN, interferon; AKT/PKB, protein kinase B; NF-κB, nucl
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; PEPD, Paroxysmal extreme pain disorder; PD, Prolidase deficiency; IgE, Immunoglobulin E; Th1, T helper cell 1; IL, Interleukins; TNF-α, Tumour necrosis factor alpha; STAT, Signal Transducer and Activator of Transcription; G, Guanine; A, AdenineProlidase d
Natural killer cells in patients with polycythemia vera
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; NK, natural killer; PV, polycythemia vera; JAK2, janus kinase 2; MPD, myeloproliferative disorders; Ph1, phildadelphia; HLA, human leukocyte antigen; STAT, signal transducer and activator of transcription; CML, chronic myeloid leukemia; KIRs, inhibitory k
Erythropoietin acts as an anti-inflammatory signal on murine mast cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; BMMC, bone marrow-derived mast cells; Epo, erythropoietin; JAK, Janus kinase; LPS, lipopolysaccharide; SCF, stem cell factor; SOCS, suppressor of cytokine signaling; STAT, signal transducer and activator of transcription; TNF, tumor necrosis factor; TPR,
Differential regulation of Tregs and Th17/Th1 cells by a sirolimus-based regimen might be dependent on STAT-signaling in renal transplant recipients
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; mTOR, mammalian target of rapamycin; MMF, mycophenolate mofetil; CNI, calcineurin inhibitor; SRL, sirolimus; TAC, tacrolimus; STAT, signal transducer and activator of transcription; mTORC1, mTOR complex 1; mTORC2, mTOR complex 2Calcineurin inhibitors; Reg
Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; HRP, horseradish peroxidase; JAK, Janus kinase; PCNA, proliferating cell nuclear antigen; PI, propidium iodide; STAT, signal transducer and activator of transcription; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end labelingApoptosis;
Toward a new STATe: The role of STATs in mitochondrial function
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; STAT, Signal Transducer and Activator of Transcription; JAK, Janus kinase; TFs, transcription factors; ETC, electron transport chain; MLS, mitochondrial localization sequence; MTS, mitochondrial targeting sequence; MEFs, mouse embryonic fibroblasts; KO, k
A perylene derivative regulates HIF-1α and Stat3 signaling pathways
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; HIF-1, hypoxia-inducible factor-1; STAT, signal transducer and activator of transcription; SRC, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; JAK, Janus kinase; ERK, extracellular signal-regulated protein kinases; AKT, serine/threonine
A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas 12
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; PIM, proviral integration site for moloney murine leukemia virus; STAT, signal transducer and activator of transcription; FLT3, fms-like tyrosine kinase 3; hERG, human ether-à-go-go-related gene; AML, acute myeloid leukemia; BAD, Bcl-2 associated death pr
Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; HCV, hepatitis C virus; NS, non-structural; TCPTP, T cell protein tyrosine phosphatase; IFN, interferon; EGFR, epidermal growth factor receptor; Jak, janus kinase; STAT, signal transducer and activator of transcription; GAPDH, glyceraldehyde 3-phosphate d
IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IFN, interferon; IRF-1, interferon regulatory factor 1; LC3, microtubule associated light chain 3; TNF-α, tumor necrosis factor-α; STAT, signal transducer and activator of transcription; ChIP, chromatin immunoprecipitationOptineurin; IFN-γ; IRF-1; Promote
Indoxyl 3-sulfate stimulates Th17 differentiation enhancing phosphorylation of c-Src and STAT3 to worsen experimental autoimmune encephalomyelitis
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; AhR, aryl hydrocarbon receptor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; I3S, 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazolo[3,4-d]pyrimidine; Th, helper T cell; STAT, signal transducer and activator of transcription; EAE, experimental autoimmune encep
The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; MLF, 4′-Methoxy licoflavanone; AIF, Alpinumisoflavone; STAT, Signal Transducer and Activator of Transcription; Δψm, mitochondrial membrane potential; MTT, 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide; PI, propidium iodide; PTP, mitochondr
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Indirubin derivative (IRD); JAK; SFK; Stat3; ApoptosisIRD, indirubin derivative; STAT, signal transducer and activator of transcription; JAKs, Janus kinases; SFKs, Src family kinases; Tyk2, tyrosine kinase 2; AAD, All-Around Docking; MD, molecular dynamic
Thymic stromal lymphopoietin promotes the proliferation of human trophoblasts via phosphorylated STAT3-mediated c-Myc upregulation
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; TSLP; c-Myc; STAT3 pathway; Trophoblast; ProliferationTSLP, thymic stromal lymphopoietin; STAT, signal transducer and activator of transcription; DCs, dendritic cells; BrdU, Bromo deoxy Uridine
IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; AD, atopic dermatitis; DN, dominant negative; FBS, fetal bovine serum; Jak, Janus kinase; Stat, signal transducer and activator of transcription; TBS, Tris-buffered saline; Tg, transgenicIL-4; CCL26; Gene regulation; Atopic dermatitis
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Berbamine derivatives (BBMDs); Jak2; Stat3; ApoptosisBBMDs, berbamine derivatives; STAT, signal transducer and activator of transcription; JAKs, Janus kinases; SFKs, Src family kinases; Tyk2, tyrosine kinase 2; CML, chronic myelogenous leukemia
Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; EGF, epidermal growth factor; IL-6, interleukin-6; MMP, matrix metalloproteinase; STAT, signal transducer and activator of transcription; TIMP, tissue inhibitor of metalloproteinase; uPA, urokinase-type plasminogen activator; VEGF, vascular endothelial gr
The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IFN, Interferon; STAT, Signal Transducer and Activator of Transcription; PI3K, phosphatidylinositol 3 kinase; EGF, epidermal growth factor; IGF-I, insulin-like growth factor I; MAPK, mitogen-activated protein kinase; PPAR-γ, peroxisome proliferator-activa
Nuclear translocation of phosphorylated STAT3 regulates VEGF-A-induced lymphatic endothelial cell migration and tube formation
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; VEGF; STAT1; STAT3; Lymphatic endothelial cell; Migration; Tube formationVEGF, vascular endothelial growth factor; LEC, lymphatic endothelial cell; STAT, signal transducer and activator of transcription; p-STAT3, phosphorylated STAT3; HDMEC, human dermal
Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; EGFR, epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; PI3K, phosphatidyl inositol 3-kinase; STAT, signal transducer and activator of transcription; PKC, protein kinase C; PLD, phospholipase D; EEA1, early endosomal antigen 1; APP
Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Tr1 cells, type 1 regulatory T cells; TH17, T helper 17; Stat, signal transducer and activator of transcription; Maf, transcription factor Maf; Ahr, Aryl hydrocarbon receptorIL-27; TH17 cells; Tr1 cells; Foxp3+ regulatory T cells; Stat; Maf
Intact JAK–STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IFN, interferon; STAT, signal transducer and activator of transcription; IRF, IFN regulatory factor; JAK, Janus-activated kinase; ISGF-3, IFN-stimulated gene factor-3; ISRE, IFN-stimulated response element; ATRA, all trans retinoic acidIFN; RIG-G; STAT1;
Systems biology of JAK-STAT signalling in human malignancies
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; JAK-STAT; Cell signalling; Interferon-γ; Pancreatic stellate cell; STAT1; Mathematical modellingJAK, Janus kinase; STAT, signal transducer and activator of transcription; IFN, interferon; SOCS, suppressor of cytokine signalling; PIAS, protein inhibitors o
Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; STAT, signal transducer and activator of transcription; GRIM-19, genes associated with retinoid-interferon-induced mortality-19; ETC, electron transport chain; PDC, pyruvate dehydrogenase complex; PBC, primary biliary cirrhosis; IL-3, interleukin-3; SOCS,
Tissue inhibitor of matrix metalloproteinase-1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; EPO, Erythropoietin; HI, Hypoxia Ischemia; JAK, Janus Kinase; MMP, Matrix Metalloproteinase; NGF, Neuronal Growth Factor; OGD, Oxygen and Glucose Deprivation; STAT, Signal Transducer and Activator of Transcription; TIMP, Tissue Inhibitor of matrix Metallo
Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IL-4, interleukin-4; IgE, immunoglobulin E; IL-4R, interleukin-4 receptor; εGT, ε germline transcript; γc, common gamma chain; STAT, signal transducer and activator of transcription; JAK, Janus kinase; PPARγ, peroxisome proliferator-activated receptorFlav
Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; BSM, bronchial smooth muscle; AHR, airway hyperresponsiveness; MLC, myosin light chain; IL, interleukin; STAT, signal transducer and activator of transcription; hEGF, human epidermal growth factor; hFGF-b, human fibroblast growth factor-basic; GAPDH, glyc
Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; STAT, signal transducer and activator of transcription; PDC-E2, E2 component of pyruvate dehydrogenase complex; ETC, electron transport chain; IFN, interferon; IL, interleukin; PBS, phosphate-buffered saline; VDAC1, voltage-dependent anion-selective chann
Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-γ-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; NO, nitric oxide; iNOS, inducible nitric oxide synthase; IFN-γ, interferon-gamma; GAS, gamma-activated sequence; STAT, signal transducer and activator of transcription; JAK, Janus tyrosine kinase; IRF-1, interferon-regulatory factor-1; MAPK, mitogen-activ
Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; SOCS, suppressors of cytokine signalling; FAK, focal adhesion kinase; GM-CSF, granulocyte macrophage-colony stimulating factor; IL, interleukin; IFN, interferon; JAK, Janus kinase; STAT, signal transducer and activator of transcription; GEF, guanine nucle
Thymic stromal lymphopoietin–induced human asthmatic airway epithelial cell proliferation through an IL-13–dependent pathway
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Asthma; cytokines; engineered bronchial tissue; epithelial cellsEGF, Epidermal growth factor; EGFR, Epidermal growth factor receptor; IL-7Rα, IL-7 receptor α chain; STAT, Signal transducer and activator of transcription; TSLP, Thymic stromal lymphopoietin
Active immune response protects Stat6VT transgenic mice from developing a lymphoproliferative disorder
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Gfi-1; Immunization; Lymphocyte; Lymphoma; Proliferation; Stat6LPD, lymphoproliferative disorder; Ig, immunoglobulin; STAT, signal transducer and activator of transcription; IL, interleukin; RT-PCR, reverse-transcriptase polymerase chain reaction; CFA, co
The proximal STAT6 and NF-κB sites are responsible for IL-13- and TNF-α-induced RhoA transcriptions in human bronchial smooth muscle cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; BSM, bronchial smooth muscle; IL, interleukin; TNF, tumor necrosis factor; STAT, signal transducer and activator of transcription; NF-κB, nuclear factor κB; AHR, airway hyperresponsiveness; hBSMCs, human bronchial smooth muscle cells; IKK, IκB kinase; siR
Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Stat, Signal Transducer and Activator of Transcription; Prl, prolactin; PrlR, prolactin receptor; AR, androgen receptorStat5a/b; Prostate cancer; Therapy development
Jnk signaling pathway-mediated regulation of Stat3 activation is linked to the development of doxorubicin resistance in cancer cell lines
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; DOX, doxorubicin; phospho, phosphorylation; Stat, signal transducer and activator of transcription; Jnk, c-Jun N-terminal kinase; AP1, activator protein-1; NF-kB, nuclear factor-kappa B; Erk, RAS/extracellular signal-regulated kinase; Jak, Janus kinase; F
Direct evidence for leptin-induced lipid oxidation independent of long-form leptin receptor
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; JAK, janus kinase; STAT, signal transducer and activator of transcription; p38 MAPK, p38 mitogen-activated protein kinaseLeptin; db/db mouse; Primary myotube; STAT3 siRNA; p38 MAPK siRNA
Hepatitis B virus overexpresses suppressor of cytokine signaling-3 (SOCS3) thereby contributing to severity of inflammation in the liver
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; HBV, hepatitis B virus; STAT, signal transducer and activator of transcription; SOCS, suppressor of cytokine signaling; IHC, immunohistochemistry; AdHBV, HBV-expressing adenovirus constructs; HCC, hepatocellular carcinoma; IFN, interferon; JAK, janus kina
Chronic leptin treatment stimulates lipid oxidation in immortalized and primary mouse skeletal muscle cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; MCAD, medium-chain acyl-CoA dehydrogenase; CPT, carnitine palmitoyltransferase; UCP, uncoupling protein; JAK, janus kinase; STAT, signal transducer and activator of transcription; DMEM, Dulbecco's modified high-glucose Eagle's medium; AMPK, 5′-AMP-activat
Glycogen synthase kinase-3 promotes the synergistic action of interferon-γ on lipopolysaccharide-induced IL-6 production in RAW264.7 cells
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; GSK3, glycogen synthase kinase-3; IL-6, interleukin-6; IFN, interferon; JAK, Janus kinase; LiCl, lithium chloride; LPS, lipopolysaccharide; NF-κB, nuclear factor kappa B; STAT, signal transducer and activator of transcription; TLR, Toll-like receptor; TNF
Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-α: relevance to hepatitis C
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; HCV, hepatitis C virus; IFNα, interferon-α; JAK, Janus kinase; STAT, signal transducer and activator of transcription; ISGF, interferon-stimulated gene factor; ISG, interferon-stimulated gene; ISRE, interferon-α-stimulated response elements; IRF, interfer
IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Human primary keratinocytes; eczema; inflammation; IL-6/IL-12 family; chemokinesAPC, Antigen-presenting cell; EBI3, EBV-induced gene 3; gp130, Glycoprotein 130; IL-18Rα, IL-18 receptor α; STAT, Signal transducer and activator of transcription; TRAIL, TNF-
Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; cAMP, cyclic AMP; HUVECs, human umbilical vein endothelial cells; sIL-6Rα, soluble IL-6 receptor α; ERK, extracellular signal-regulated kinase; STAT, signal transducer and activator of transcription; siRNA, short interfering RNA; SOCS, suppressor of cytok
STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IL-1β, interleukin 1 beta; LPS, lipopolysacharide; IL-6, interleukin-6; JAK, Janus-activated kinase; INFγ, interferon gamma; ICE, IL-1β converting enzyme; TLR4, toll like receptor 4; STAT, signal transducer and activator of transcription; PTK, protein-tyr
Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; GBM, glioblastoma multiforme; ROS, reactive oxygen species; STAT, signal transducer and activator of transcription; NAC, N-acetylcysteineGlioblastoma; ROS; STAT3; Telomerase; Manumycin; Free radicals
Csk-binding protein can regulate Lyn signals controlling cell morphology
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; Csk, COOH-terminal Src kinase; Cbp, Csk binding protein; SH2, Src homology 2; SH3, Src homology 3; Epo, erythropoietin; SOCS1, suppressor of cytokine signaling 1; STAT, signal transducer and activator of transcription; JAK, Janus kinase; PLCγ, phspholipas
IFN-γ down-regulates ABCA1 expression by inhibiting LXRα in a JAK/STAT signaling pathway-dependent manner
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IFN-γ, interferon gamma; ABCA1, ATP-binding cassette transporter A1; JAK, Janus kinase; STAT, signal transducer and activator of transcription; LXRs, liver X receptors; TC, total cholesterol; FC, free cholesterol; CE, cholesterol esterATP-binding cassette
The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29
Keywords: STAT، مبدل سیگنال و فعال کننده رونویسی; IL; cytokine; IL-10–related cytokinesAPC, Antigen-presenting cell; DC, Dendritic cell; Jak, Janus kinase; STAT, Signal transducer and activator of transcription