کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3391539 | 1221057 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27 Induction of regulatory Tr1 cells and inhibition of TH17 cells by IL-27](/preview/png/3391539.png)
Accumulating evidence indicates that IL-27, a member of the IL-12 family of cytokines, alleviates the severity of autoimmune diseases in both mice and men. The IL-27-induced activation of signal transducer and activator of transcription (Stat)1 and Stat3 promotes the generation of IL-10- producing type 1 regulatory T (Tr1) cells that inhibit effector T cells. In addition, IL-27 also suppresses the development of pathogenic IL-17-producing CD4+ T cells (TH17) cells suggesting that pharmacological manipulations of IL-27 signaling pathway could be exploited therapeutically in regulating tissue inflammation. Here, we review how IL-27 controls inflammation through the regulation of Tr1 and TH17 responses.
► IL-27 controls autoimmune responses by promoting Tr1 cells and inhibiting TH17 cells.
► IL-27 triggers Stat1 and Stat3 signaling.
► IL-27 induces Maf and AhR that control IL-10 secretion from Tr1 cells.
► Stat1 activation represses TH17 cells and induces Tr1 cells.
► IL-27 alleviates human autoimmune diseases.
Journal: Seminars in Immunology - Volume 23, Issue 6, December 2011, Pages 438–445