کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2070272 | 1078480 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Systems biology of JAK-STAT signalling in human malignancies Systems biology of JAK-STAT signalling in human malignancies](/preview/png/2070272.png)
Originally implicated in the regulation of survival, proliferation and differentiation of haematopoietic cells, the JAK-STAT pathway has also been linked to developmental processes, growth control and maintenance of homeostasis in a variety of other cells and tissues. Although it remains a complex system, its relative simplicity and the availability of molecular data makes it particularly attractive for modelling approaches. In this review, we will focus on JAK-STAT signalling in the context of cancer and present efforts to investigate signalling dynamics with the help of mathematical models. We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells.
Journal: Progress in Biophysics and Molecular Biology - Volume 106, Issue 2, August 2011, Pages 426–434