Keywords: AMPK; AMP-activated protein kinase; ARF6; ADP-ribosylation factor 6; AKT; protein kinase B; BBB; blood brain barrier; bFGF; b-fibroblast growth factors; b-FGFR; b-fibroblast growth factors receptor; ccRCC; clear cell renal cell carcinoma; ECs; endothelial
مقالات ISI (ترجمه نشده)
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Keywords: AMPK; AMP-activated protein kinase; BLM; bleomycin; COX 2; cycloxigenase-2; EMT; epithelial mesenchymal transition; GPx; glutathione peroxidase; GST; gluthatione S transferase; HYP; hydroxyproline; IFN-α; interferon alpha; IL; interleukin; JAK-STAT; the
Keywords: Aptamer; Apoptosis; Targeted therapy; Intrinsic apoptosis pathway; Extrinsic apoptosis pathway; Intramer; Akt; PKB (protein kinase B); Bcl; B-cell lymphoma family protein; BH; Bcl-2 homology domain; Bmi-1; B lymphoma Mo-MLV insertion region 1; CD; cluster
Keywords: Epilepsy; Epileptogenesis; Epigenetics; Neurosteroid; JAK-Stat; Rapamycin;
Keywords: acupuncture; inflammation; JAK-STAT; NF-κB; MAPK;
Keywords: OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: Leptin; Leptin receptor; JAK-STAT; Neuropeptide; ob Gene; db Gene
Keywords: Alzheimer's disease; Neuro-inflammation; Type-1 interferons; JAK-Stat; Interleukin-1β; Interleukin-6;
Keywords: Delay differential equations; Functional data analysis; JAK-STAT; Nonlinear regression; Model based smoothing;
IL-9 exhibits elevated expression in osteonecrosis of femoral head patients and promotes cartilage degradation through activation of JAK-STAT signaling in vitro
Keywords: Interleukin-9; JAK-STAT; Inflammation; Osteonecrosis of the femoral head; TNF-α;
Phoenixin participated in regulation of food intake and growth in spotted scat, Scatophagus argus
Keywords: Pnx; phoenixin; ghrhr; growth hormone-releasing hormone receptor; gh; growth hormone; ghr; growth hormone receptor; Igf; insulin-like growth factor; Ghrh; growth hormone-releasing hormone; PVN; paraventricular nucleus; Arc; arcuate nucleus; VMH; ventromed
Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism
Keywords: Alcohol; HCV; JMJD6; STAT1; Ach; acetaldehyde; ADH; alcohol dehydrogenase; AGS; acetaldehyde-generating system; AMI-1; protein arginine N-methyltransferase inhibitor; BHMT; betaine-homocysteine-S-methyltransferase; cDNA; complementary DNA; CYP2E1; cytochr
Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver
Keywords: PRR; Virus Immune Evasion; PAMP; Ex Vivo; CHB; chronic hepatitis B; CTRL; uninfected control; dsRNA; double-stranded RNA; HBcAg; HBV core protein; HBeAg; hepatitis B e antigen; HBsAg; HBV surface protein; HBV; hepatitis B virus; IFN; interferon; ISG; in
Curcumin-loaded nanoparticles ameliorate glial activation and improve myelin repair in lyolecithin-induced focal demyelination model of rat corpus callosum
Keywords: MS; Multiple sclerosis; CNS; Central nervous system; AD; Alzheimer's disease; PD; Parkinson's disease; JAK-STAT; Janus kinase-signal transducer and activator of transcription; EAE; Experimental autoimmune encephalomyelitis; NPs; Nanoparticles; CS; Chi
Optimizing conventional DMARD therapy for Sjögren's syndrome
Keywords: 6-MP; 6-mercaptopurine; 6-T-GTP; 6-thioguanine triphosphate; ABT; abatacept; Ach; acetylcholine; ALAT; alanine amino transferase; AZA; azathioprine; BAFF; B cell activating factor; Bcl-6; B cell lymphoma 6; bDMARDs; biological disease modifying antirheuma
High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s
Kaempferol 7-O-β-D-glucoside isolated from the leaves of Cudrania tricuspidata inhibits LPS-induced expression of pro-inflammatory mediators through inactivation of NF-κB, AP-1, and JAK-STAT in RAW 264.7 macrophages
Keywords: Kaempferol 7-O-β-D-glucoside; NF-κB; AP-1; JAK-STAT; RAW 264.7 macrophages;
Gene expression profiling provides insights into the immune mechanism of Plutella xylostella midgut to microbial infection
Keywords: AMP; Antimicrobial peptide; A. gambiae; Anopheles gambiae; B. mori; Bombyx mori; Bt; Bacillus thuringiensis; Cec; Cecropin; clip-SP; Clip-domain serine protease; clip-SPH; Clip-domain serine protease homolog; CTL; C-type lectin; D. melanogaster; Drosophil
Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome
Keywords: IFN; interferon; ISGs; IFNstimulated genes; HCV; hepatitis C virus; IL-10; interleukin-10; PDL-1; programmed death-ligand 1; LCMV; lymphocytic choriomeningitis virus; IFNAR; IFNA receptor; IRFs; IFN regulatory factors; pDCs; plasmacytoid dendritic cells;
Comparative transcriptome analysis of ovary and testis reveals potential sex-related genes and pathways in spotted knifejaw Oplegnathus punctatus
Keywords: cDNA; complementary deoxyribonucleic acid; NR; non-redundant protein databases; KOG; eukaryotic orthologus groups; KEGG; kyoto encyclopedia of genes and genomes; GO; gene ontology; qRT-PCR; quantitative real-time polymerase chain reaction; foxl2; forkhead
The innate immune response to RSV: Advances in our understanding of critical viral and host factors
Keywords: ATF6; activated transcription factor 6; BAP31; B-cell receptor-associated protein 31; Bcl2; B-cell lymphoma 2; DR4/5; death receptor 4/5; DUOX2; dual oxidase 2; DVGs; defective viral genomes; IB; inclusion body; IFIT1; interferon-induced protein with tetr
Molecular characterization and expression analysis of interferon-gamma in black seabream Acanthopagrus schlegelii
Keywords: Black seabream; IFN-gamma; Red spotted grouper nervous necrosis virus; JAK-STAT; ISG; AP-1; activator protein 1; bp; base pair; CaMKII; calcium/calmodulin kinase II; GAS; gamma IFN-activated sequences; ORF; open reading frame; GATA3; GATA-binding protein
JAK-STAT signaling in the therapeutic landscape of myeloproliferative neoplasms
Keywords: JAK-STAT; Myeloproliferative neoplasm; JAK inhibitor; Ruxolitinib; Primary myelofibrosis;
JAK inhibitors in dermatology: The promise of a new drug class
Keywords: alopecia areata; atopic dermatitis; baricitinib; JAK inhibitor; JAK-STAT; psoriasis; ruxolitinib; tofacitinib; vitiligo; AA; alopecia areata; AD; atopic dermatitis; AT; alopecia totalis; AU; alopecia universalis; CANDLE; chronic atypical neutrophilic derm
Cardiac overexpression of Epac1 in transgenic mice rescues lipopolysaccharide-induced cardiac dysfunction and inhibits Jak-STAT pathway
Keywords: Epac; exchange protein activated by cyclic AMP; PKC; protein kinase C; LVEF; left ventricular ejection fraction; TNF; tumor necrosis factor; IL; interleukin; Jak-STAT; janus kinase-signal transducers and activators of transcription; SOCS3; suppressor of c
The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting
Keywords: Congenital HCMV; Guinea pig CMV; Immediate-early 1; HSV-1; Innate immunity; Nuclear domain 10; PML; Daxx; Interferon; JAK-STAT;
DNA Methylation Regulates Gene Expression in Intracranial Aneurysms
Keywords: DNA methylation; Gene expression profile; Intracranial aneurysm; Microarray analysis; AAA; Abdominal aortic aneurysm; DEG; Differentially expressed gene; FC; Fold change; GO; Gene Ontology; JAK-STAT; Janus kinase/signal transducer and activator of transcr
Roscovitine attenuates intimal hyperplasia via inhibiting NF-κB and STAT3 activation induced by TNF-α in vascular smooth muscle cells
Keywords: VSMCs; vascular smooth muscle cells; TNF-α; tumor necrosis factor α; MAPKs; mitogen-activated protein kinases; NF-κB; nuclear factor-kappa B; JAK-STAT; Janus kinase-signal transducer and activator of transcription; IL-1β; interleukin-lβ; MCP-1; monoc
Profiling conserved biological pathways in Autosomal Dominant Polycystic Kidney Disorder (ADPKD) to elucidate key transcriptomic alterations regulating cystogenesis: A cross-species meta-analysis approach
Keywords: ADPKD; Autosomal Dominant Polycystic Kidney disease; GEO; Gene Expression Omnibus; PC1; polycystin-1; PC2; polycystin-2; DEGs; differentially expressed genes; BH; Benjamini & Hochberg; GO; Gene Ontology; GO BP; GO Biological Processes; PANTHER; Protein AN
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model
Keywords: Berberine; Experimental autoimmune myocarditis; JAK-STAT; Th17; Th1
MicroRNA transcriptome profiling of mice brains infected with Japanese encephalitis virus by RNA sequencing
Keywords: KEGG; Kyoto Encyclopedia of Genes and Genomes; SHIP1; Src homology 2-containing inositol phosphatase 1; Jak-STAT; Janus kinase-Signal Transducer and Activator of Transcription; NF-κB; nuclear factor of kappa light polypeptide gene enhancer in B-cells; If
Macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins are modulated by complement protein C1q
Keywords: Inflammation; Atherosclerosis; Innate; LDL; JAK-STAT; PPAR; acLDL; acetylated low density lipoprotein; BMDM; bone marrow derived macrophages; GO; gene ontology; HDL; high density lipoprotein; HMDM; human monocyte derived macrophages; IFN; interferon; JAK;
JAK inhibitor JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation
Keywords: JAK-STAT; Contact hypersensitivity; Skin inflammation; Cytokines; Effector memory T cell;
SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy
Keywords: ACUC; Animal Care and Use Committee; AGP; andrographolide; CDK; cyclin dependent kinase; DMSO; dimethyl sulfoxide; DOX; doxorubicin; ERK1/2; extracellular signal-regulated kinases 1/2; FBS; fetal bovine serum; HPLC; high performance liquid chromatography;
An unusual long-term outcome of a child with primary myelofibrosis harboring a JAK2 mutation
Keywords: BM; bone marrow; MPN; myeloproliferative neoplasm; CMD; chronic myeloproliferative disease; DIPSS; dynamic-IPSS; EC; endothelial cells; HSCT; hematopoietic stem cell transplantation; INCA; Instituto Nacional de Câncer; IPSS; International Prognostic Scor
C-mannosylation of thrombopoietin receptor (c-Mpl) regulates thrombopoietin-dependent JAK-STAT signaling
Keywords: Post-translational modification; C-mannosylation; Thrombopoietin receptor; c-Mpl; JAK-STAT; TPO; thrombopoietin; JAK; Janus kinase; STAT; signal transducer and activator of transcription; ECD; extracellular domain;
The role of AGR2 and AGR3 in cancer: Similar but not identical
Keywords: AGR2; AGR3; PDI family; Cancer; AA; amino acids; ALS; familial amyotrophic lateral sclerosis; AGR; anterior gradient; AhR; aryl hydrocarbon receptor; AR; androgen receptor; CAPN8; calpain 8; CAPN9; calpain 9; CDDP; cisplatin; CFTR; cystic fibrosis transme
Adenovirus-mediated transfer of the SOCS-1 gene to mouse lung confers protection against hyperoxic acute lung injury
Keywords: Ad-GFP; GFP adenovirus; Ad-SOCS-1; SOCS-1 adenovirus; AFC; alveolar fluid clearance; ALI; acute lung injury; ASK-1; apoptosis signal-regulating kinase-1; BAL; bronchoalveolar lavage; JAK-STAT; Janus kinases-signal transducer and activator of transcripti
Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR
Keywords: mgp96; uPAR; Liver cancer; MAPK; DFS; ADAMTS9; a disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; AIMP1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; AKT; v-akt murine thymoma viral oncogene homo
Pathogenesis pathways of idiopathic pulmonary fibrosis in bleomycin-induced lung injury model in mice
Keywords: Bleomycin; Idiopathic pulmonary fibrosis; Lung; Smad3; IL-31; JAK-STAT
Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways
Keywords: SOCS-1; suppressor of cytokine signaling 1; CISH; cytokine-inducible SH2-domain containing protein; IFN; interferon; MAVS; mitochondrial antiviral signaling protein; JAK-STAT; the Janus kinase signal transducer and activator of transcription; ISG; IFN-sti
MiRNA in melanoma-derived exosomes
Keywords: Biomarker; Exosome; Melanoma; MicroRNA; MiRNA; AGO-2; argonaute protein 2; BMDCs; bone marrow-derived cells; BMP4; bone morphogenetic protein 4; CCND1; cyclin D1; CDK4; cyclin-dependent kinase; DGCR8; DiGeorge critical region gene 8; EMT; epithelial to me
Study of interferon-β antiviral activity against Herpes simplex virus type 1 in neuron-enriched trigeminal ganglia cultures
Keywords: HSV-1; Herpes simplex virus type 1; TG; trigeminal ganglion; IFN; interferon; gB; HSV-1 glycoprotein B; Oas; 2â²-5â² oligoadenylate synthetase; RNase-L; latent ribonuclease or 2â²,5â²-oligoisoadenylate synthetase-dependent RNAse; Pkr; double strande
Identification of conserved and novel microRNAs in Manduca sexta and their possible roles in the expression regulation of immunity-related genes
Keywords: Posttranscriptional regulation; Illumina sequencing; Lepidoptera; Insect immunity; Target site prediction; Alk; anaplastic lymphoma kinase; AMP; antimicrobial peptides; ANKRD54; ankyrin repeat domain 54; Aop; anterior open; aPKC; atypical protein kinase C
Determination of the novel genetic variants of goat STAT5A gene and their effects on body measurement traits in two Chinese native breeds
Keywords: STATs; signal transducers and activators of transcription; JAKs; Janus kinase; JAK-STAT; Janus kinase-signal transducers and activators of transcription pathway; STAT5A; signal transducer and activator of transcription 5A; MGF; mammary gland factor; STAT5
High glucose driven expression of pro-inflammatory cytokine and chemokine genes in lymphocytes: Molecular mechanisms of IL-17 family gene expression
Keywords: MAPK; Mitogen Activated Protein Kinase; JAK-STAT; Janus Activated Kinase-Signal Transducer and Activator of Transcription; ERK; Extracellular Regulated Kinase; FOXP3; Forkhead box P3; LDLR; LDL Receptor; BMP-2; Bone Morphogenic Protein-2; PTX3; Pentraxin-
Research ArticleSequential induction of type I and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist
Keywords: HCV; hepatitis C virus; IFN; interferon; TLR; Toll-like receptor; Jak-STAT; Janus kinase-signal transducer and activator of transcription; ISG; interferon-stimulated gene; PBMCs; peripheral blood mononuclear cells; IMO; immunomodulatory oligonucleotide; K
Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands
Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat
Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition
Keywords: Phosphatase; Cytokine signaling; Protein–protein interaction; Crystal structure; JAK-STAT; PTP1B
JAK-STAT pathway modulates the roles of iNOS and COX-2 in the cytoprotection of early phase of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress
Keywords: H2O2 preconditioning; Early phase; JAK-STAT; iNOS; COX-2; Cytoprotection