کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8943688 | 1645201 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phoenixin participated in regulation of food intake and growth in spotted scat, Scatophagus argus
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کلمات کلیدی
PNXGHRHRPI3KJAK-STATIGFVMHintracerebroventricularlyERKICVGHRHGHRAkt - آکتGrowth - رشدPhoenixin - عنقاInsulin-like growth factor - فاکتور رشد مانند انسولینphosphoinositide 3-kinase - فسفینوزیتید 3-کینازArc - قوسPVN - مالیات بر ارزش افزودهfood intake - مصرف غذاarcuate nucleus - هسته قوسparaventricular nucleus - هسته پروژسترویکgrowth hormone-releasing hormone - هورمون آزاد کننده هورمون رشدGrowth hormone - هورمون رشدbody weight - وزن بدنprotein kinase B - پروتئین کیناز Bextracellular regulated protein kinases - پروتئین کیناز تنظیم شده خارج سلولیGrowth hormone-releasing hormone receptor - گیرنده هورمون آزاد کننده هورمون رشدgrowth hormone receptor - گیرنده هورمون رشد
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Phoenixin (Pnx) is an endogenous peptide known to be involved in reproduction and food intake in rats, with two active isoforms, phoenixin-14 (Pnx-14) and phoenixin-20 (Pnx-20). However, little is known about the functions of Pnx in teleost. Here, pnx was cloned and was detected in all tissues of both male and female in spotted scat (Scatophagus argus), including growth axis, hypothalamus, pituitary, and liver. Real-time PCR analysis showed that pnx in the hypothalamus increased significantly after 2â¯d and 7â¯d fasting, while reduced significantly after re-feeding (Pâ¯<â¯0.05). When pituitary and liver fragments were cultured in vitro with Pnx-14 and Pnx-20 (10â¯nM and 100â¯nM) for 6â¯h, the expression of ghrhr (growth hormone-releasing hormone receptor) and gh (growth hormone) in the pituitary, and ghr1 (growth hormone receptor 1) in the liver increased significantly, except ghr2 (growth hormone receptor 2) incubated with 10â¯nM and 100â¯nM Pnx-20 and ghr1 incubated with 10â¯nM Pnx-20. Similarly, the expression of ghrhr and gh in the pituitary, as well as ghr1 and ghr2 in the liver, increased significantly after injecting S. argus with Pnx-14 and Pnx-20 (10â¯ng/g and 100â¯ng/g body weight). These results indicate that Pnx is likely to be involved in the regulation of food intake, and also regulates the growth of S. argus by increasing ghrhr and gh expression in the pituitary, ghr1 and ghr2 in the liver, and ghr1 directly in the liver.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Volume 226, December 2018, Pages 36-44
Journal: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Volume 226, December 2018, Pages 36-44
نویسندگان
Mei Wang, Si-Ping Deng, Hua-Pu Chen, Dong-neng Jiang, Chang-Xu Tian, Wei Yang, Tian-li Wu, Chun-Hua Zhu, Yong Zhang, Guang-Li Li,