کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052675 | 1074235 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Afaf, a novel vesicle membrane protein, is related to acrosome formation in murine testis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
As a cell-specific organelle, acrosome (Acr) and its formation are an important event for spermiogenesis. However, the Acr formation is far more complicated than has been proposed. In this study, we have cloned a novel membrane protein Afaf (Acr formation associated factor) that was expressed abundantly in the round spermatids, localized in the inner and outer membrane of forming Acrs, and declined in the maturing Acrs. In the transfected Hela cells, Afaf protein was localized in the plasma membrane, EEA1-positive early endosomes (EEs) and occasionally in the nuclei. Therefore, we propose that EEs and plasma membrane may be also directly involved in the Acr biogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 17, 24 July 2006, Pages 4266–4273
Journal: FEBS Letters - Volume 580, Issue 17, 24 July 2006, Pages 4266–4273
نویسندگان
Yin-Chuan Li, Xiao-Qian Hu, Ke-Ying Zhang, Jian Guo, Zhao-Yuan Hu, Shi-Xin Tao, Li-Juan Xiao, Qing-Zhong Wang, Chun-Sheng Han, Yi-Xun Liu,