کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052905 1074244 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis – involvement of ERK pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis – involvement of ERK pathway
چکیده انگلیسی

Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H2O2-induced cell death – a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H2O2 (0–2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 11, 15 May 2006, Pages 2779–2787
نویسندگان
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