کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052923 1074245 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Upregulation of hypoxia-induced mitogenic factor in bacterial lipopolysaccharide-induced acute lung injury
چکیده انگلیسی

Hypoxia-induced mitogenic factor (HIMF), also known as FIZZ1 (found in inflammatory zone), plays important roles in lung inflammation. We found that intraperitoneal injection of lipopolysaccharide (LPS) induced intensive HIMF production exclusively in mouse lung, but not in the heart, liver, spleen or kidney. This HIMF production, at least partly, contributes to LPS-induced vascular cell adhesion molecule-1 (VCAM-1) upregulation and mononuclear cell sequestration to lung parenchyma, while protecting alveolar type II cells from LPS-resulted decrease in surfactant protein-C production and cell death. These data indicate that HIMF participates in LPS-induced acute lung injury and inflammation through modulating VCAM-1 and SP-C expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 9, 17 April 2006, Pages 2207–2215
نویسندگان
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