کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2052946 1074245 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of human d-amino acid oxidase
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
Characterization of human d-amino acid oxidase
چکیده انگلیسی

d-Amino acid oxidase (DAAO) has been proposed to be involved in the oxidation of d-serine, an allosteric activator of the NMDA-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia. The recombinant human DAAO was expressed in Escherichia coli and was isolated as an active homodimeric flavoenzyme. It shows the properties of the dehydrogenase-oxidase class of flavoproteins, possesses a low kinetic efficiency, and follows a ternary complex (sequential) kinetic mechanism. In contrast to the other known DAAOs, the human enzyme is a stable homodimer even in the apoprotein form and weakly binds the cofactor in the free form.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 9, 17 April 2006, Pages 2358–2364
نویسندگان
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