کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2053090 | 1074255 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Riccardin C: A natural product that functions as a liver X receptor (LXR)α agonist and an LXRβ antagonist
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Riccardin C: A natural product that functions as a liver X receptor (LXR)α agonist and an LXRβ antagonist Riccardin C: A natural product that functions as a liver X receptor (LXR)α agonist and an LXRβ antagonist](/preview/png/2053090.png)
چکیده انگلیسی
Liver X receptors (LXRs) α and β share considerable sequence homology and several functions, respond to the same endogenous and synthetic ligands, and play critical roles in maintaining lipid homeostasis. In this study, liverwort-derived riccardin C (RC) and F (RF) were identified as an LXRα agonist/LXRβ antagonist and an LXRα antagonist, respectively. RC and RF bound to LXRs, but had different abilities to recruit a coactivator and thereby induce transactivation. Despite its unique subtype-selective activity, RC enhanced ABCA1 and ABCG1 expression and cellular cholesterol efflux in THP-1 cells. RC may provide a novel tool for identifying subtype-function and drug development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 24, 10 October 2005, Pages 5299–5304
Journal: FEBS Letters - Volume 579, Issue 24, 10 October 2005, Pages 5299–5304
نویسندگان
Norimasa Tamehiro, Yoji Sato, Takuo Suzuki, Toshihiro Hashimoto, Yoshinori Asakawa, Shinji Yokoyama, Tohru Kawanishi, Yasuo Ohno, Kazuhide Inoue, Taku Nagao, Tomoko Nishimaki-Mogami,