Keywords: LXR، گیرنده کبد X; StAR, steroidogenic acute regulatory protein; retinoids, retinoic acid (RA) and its derivatives; atRA, all-trans RA; (Bu)2cAMP, dibutyryl cAMP, RAR, retinoic acid receptor; RXR, retinoid X receptor; LXR, liver X receptor; ABCA1, ATP-binding cassette trans
مقالات ISI LXR، گیرنده کبد X (ترجمه نشده)
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Keywords: LXR، گیرنده کبد X; DBD, DNA-binding domain; DMSO, dimethylsulfoxide; DHA, docosahexaenoic acid; ER, estrogen receptor; HFD, high fat diet; LBD, ligand-binding domain; LXR, liver X receptor; MSC, multipotent stromal stem cell; NR, nuclear receptor; PPAR, peroxisome prolifera
Keywords: LXR، گیرنده کبد X; ACC, acetyl-CoA carboxylase; FASN, fatty acid synthase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GMECs, goat mammary gland epithelial cells; LXR, liver X receptor; NF-Y, nuclear factor Y; PPARα, peroxisome proliferator-activated receptor α; SCD, s
Keywords: LXR، گیرنده کبد X; 3α-diol, 5α-androstane-3α, 17β-diol; 5α-R, 5α-reductase; 17β-E, 17β-estradiol; AR, androgen receptor; DHEA, dehydroepiandrosterone; DHP, dihydroprogesterone; DHT, dihydrotestosterone; DRG, dorsal root ganglia; P0, glycoprotein zero; LXR, liver X receptor;
Keywords: LXR، گیرنده کبد X; AQPs, aquaporins; DUOX1, dual oxidase I; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; LXR, liver X receptor; NHEK, normal human epidermal keratinocytes; PPARγ, peroxisome proliferators-activated receptor gamma; RA, retinoic acid; SG, stratum granulosu
Keywords: LXR، گیرنده کبد X; AEH, atypical endometrial hyperplasia; CLA, conjugated linoleic acid; ERα, estrogen receptor alpha; GRAS, Generally Regarded as Safe; LA, linoleic acid; LXR, Liver X Receptor; PE, polyethyleneimine; ROS, reactive oxygen species; RCC, renal cell carcinoma;
Keywords: LXR، گیرنده کبد X; ApoC3, apolipoprotein C III; CK-18, cytokeratin-18; DAG, diacylglycerol; ER, endoplasmic reticulum; HCC, hepatocellular carcinoma; LPS, lipopolysaccharide; LXR, liver X receptor; MET, metabolic equivalent of task; NAFLD, nonalcoholic fatty liver disease;
E17110 promotes reverse cholesterol transport with liver X receptor β agonist activity in vitro
Keywords: LXR، گیرنده کبد X; ABCA1, ATP-binding cassette transporter A1; ABCG1, ATP-binding cassette transporter G1; ApoA-I, apolipoprotein A-I; GAPDH, glyceraldehyde-phosphate dehydrogenase; HDL, high-density lipoprotein; LBD, ligand-binding domain; LXR, liver X receptor; LXRE, LXR
Liver X Receptor (LXR) in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, mRNA tissue expression and transcriptional regulation by insulin in vivo and in vitro
Keywords: LXR، گیرنده کبد X; AF, activation function; BW, body weight; DBD, DNA binding domain; LBD, ligand binding domain; LXR, liver X receptor; LXRE, LXR responsive elements; ORF, open reading frame; SEM, standard error of means; UTR, untranslated regionsPelteobagrus fulvidraco; l
MDG-1, an Ophiopogon polysaccharide, alleviates hyperlipidemia in mice based on metabolic profile of bile acids
Keywords: LXR، گیرنده کبد X; FXR, farnesoid X receptor; LXR, liver X receptor; NAFLD, nonalcoholic fatty liver disease; FOS, fructooligosaccharides; DIO, diet-induce obese; UPLC–MS, ultra-performance liquid chromatography mass-spectrometry; CA, cholic acid; CDCA, chenodeoxycholic aci
The Nutrient-Dependent O-GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase
Keywords: LXR، گیرنده کبد X; HCD, high-carbohydrate diet; FAS, fatty acid synthase; HBP, hexosamine biosynthesis pathway; PTM, post-translational modification; OGT, O-GlcNAc transferase; OGA, O-GlcNAcase; ChREBP, carbohydrate responsive element-binding protein; LXR, liver X receptor;
Activation of LXRs using the synthetic agonist GW3965 represses the production of pro-inflammatory cytokines by murine mast cells
Keywords: LXR، گیرنده کبد X; Cell degranulation; Cytokines; IgE receptor; Liver X receptor; Mast cellsBMMCs, bone marrow-derived murine mast cells; FcεRI, high-affinity IgE receptor; LXR, liver X receptor; OHC, hydroxycholesterol; LPS, lipopolysaccharide; DEX, dexamethasone; Ag, anti
Growth performance, lipid deposition and hepatic lipid metabolism related gene expression in juvenile turbot (Scophthalmus maximus L.) fed diets with various fish oil substitution levels by soybean oil
Keywords: LXR، گیرنده کبد X; LPL, lipoprotein lipase; CPT I, carnitine palmitoyltransferase I; PPARα, peroxisome proliferator-activated receptor alpha; LXR, liver X receptor; FAS, fatty acid synthase; SREBP-1, sterol regulatory element-binding protein 1; MTP, microsomal triacylglycer
Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis
Keywords: LXR، گیرنده کبد X; BGP, Brazilian green propolis; FBS, fetal bovine serum; HEK, human embryonic kidney; LBD, ligand binding domain; LXR, liver X receptor; NR, nuclear receptor; PPAR, peroxisome proliferator-activated receptor; RAR, retinoic acid receptor; RXR, retinoid X re
LXR antagonists induce ABCD2 expression
Keywords: LXR، گیرنده کبد X; ACOX, Acyl-CoA oxidase; ABC, ATP binding cassette; DHA, docosahexaenoic acid (C22:6 n − 3); H2DCFDA, 2′,7′-dichlorodihydrofluorescein diacetate; HC, hydroxycholesterol; HFD, high fat diet; LXR, Liver X receptor; LXRE, LXR response element; MTE, multiple t
Metabolomics using GC–TOF–MS followed by subsequent GC–FID and HILIC–MS/MS analysis revealed significantly altered fatty acid and phospholipid species profiles in plasma of smokers
Keywords: LXR، گیرنده کبد X; Metabolomics; HILIC–MS/MS; Phospholipids; Plasma fatty acids; Monounsaturated fatty acids; Stearoyl Coenzyme A desaturase 1COPD, chronic obstructive pulmonary disease; CVD, cardiovascular diseases; FAME, fatty acid methyl ester; LXR, liver X receptor; MUF
Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells
Keywords: LXR، گیرنده کبد X; AhR, Aryl hydrocarbon Receptor; CAR, Constitutive androstane receptor; ER, estrogen receptor; GR, glucocorticoid receptor; LXR, liver X receptor; PXR, pregnane X receptor; RXR, retinoic X receptor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinArtificial sweet
Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells
Keywords: LXR، گیرنده کبد X; SULT, sulfotransferase; LXR, Liver X receptor; GEN, genistein; DHEA, dehydroepiandrosterone; hSULT2A1, human dehydroepiandrosterone sulfotransferase (DHEA-ST)Sulfotransferase; Genistein; Liver X receptor; SULT2A1; Gene regulation
Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo
Keywords: LXR، گیرنده کبد X; ABC, adenosine triphosphate-binding cassette transporter; apo, apolipoprotein; CYP7A1, cholesterol 7 alpha-hydroxylase; HDL, high-density lipoprotein; LXR, liver X receptor; SIRT1, NAD+-dependent deacetylase sirtuin 1; RCT, reverse cholesterol transport;
ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose
Keywords: LXR، گیرنده کبد X; ABCG1, ATP binding cassette transporter G1; HAECs, human aortic endothelial cells; NOS, nitric oxide synthase; eNOS, endothelial nitric oxide synthase; ROS, reactive oxygen species; LXR, liver X receptor; ICAM, intracellular adhesion molecules; HDL, high
Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high-fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages
Keywords: LXR، گیرنده کبد X; AM, alveolar macrophages; LXR, liver X receptor; ABCA1, ATP-binding cassette, sub-family A, member 1; ABCG1, ATP-binding cassette, sub-family G, member 1; L. paracasei, Lactobacillus paracasei; LPS, lipopolysacharide; CE, cholesteryl-esters; C, control di
Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells
Keywords: LXR، گیرنده کبد X; Jak2, Janus kinase 2; Stat3, signal transducer and activator of transcription 3; HSC, hepatic stellate cell; SREBP-1c, sterol regulatory element binding protein-1c; LXR, liver X receptor; FBS, fetal bovine serum; DMEM, Dulbecco's modified Eagle's medium;
Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids
Keywords: LXR، گیرنده کبد X; Amacr, α-methylacyl-CoA racemase; FXR, farnesoid X receptor; IBAT, ileal bile acid transporter (known also as the sodium-dependent bile acid transporter ASBT); LXR, liver X receptor; PPAR, peroxisome proliferator-activated receptor; CDCA, chenodeoxycholic
Sesquiterpene action, and morphogenetic signaling through the ortholog of retinoid X receptor, in higher Diptera
Keywords: LXR، گیرنده کبد X; RXR, retinoid X receptor; EcR, ecdysone receptor; USP, ultraspiracle; FXR, farnesoid X receptor; LXR, liver X receptor; JH, juvenile hormone; Met, Methoprene tolerant; 20E, 20-hydroxy ecdysone; PTG, prothoracic gland; MDCF, methyl dichlorofarnesoate; MCFs
1,4-Chirality transfer via the ester enolate Claisen rearrangements in the preparation of (25R)- and (25S)-cholestenoic acids
Keywords: LXR، گیرنده کبد X; DMAP, 4-dimethylaminopyridine; HMPA, hexamethylphosphoramide; LXR, liver X receptor; TBSCl, tert-butyldimethylsilyl chlorideCholestenoic acids; Dafachronic acids; Ireland-Claisen rearrangement; Orthoester Claisen rearrangement; Allenes
Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages
Keywords: LXR، گیرنده کبد X; ABCA1, ATP binding cassette transporter A1; ABCG1, ATP binding cassette transporter G1; CHD, coronary heart disease; HDAC, histone deacetylase; HDACi, HDAC inhibitor; HDL, high-density lipoprotein; LXR, liver X receptor; NCoR, nuclear receptor corepressor
Role of LXR in trout adipocytes: Target genes, hormonal regulation, adipocyte differentiation and relation to lipolysis
Keywords: LXR، گیرنده کبد X; 22(R)-OH, 22(R)-hydroxycholesterol; ABCA1, ATP-binding cassette transporter A1; DMSO, dimethyl sulfoxide; FAS, fatty acid synthase; GH, growth hormone; LA or 18:2n-6, linoleic acid; LPL, lipoprotein lipase; LXR, liver X receptor; LXRE, LXR response elemen
Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes
Keywords: LXR، گیرنده کبد X; LXR, liver X receptor; CAR, constitutive androstane receptor; RXR, retinoid X receptor; AhR, aryl hydrocarbon receptor; 24HC, 24(S)-hydroxycholesterol; 3MC, 3-methylcholanthrene; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-d
Liver X receptor activation attenuates inflammatory response and protects cholinergic neurons in APP/PS1 transgenic mice
Keywords: LXR، گیرنده کبد X; Alzheimer's disease; liver X receptor; inflammation; nuclear factor-kappaB; cholinergic neuronAD, Alzheimer's disease; APP, amyloid precursor protein; ChAT, choline acetyltransferase; HC, hippocampus; LXR, liver X receptor; MS, medial septal; MWM, Morris
FXR and PXR: Potential therapeutic targets in cholestasis
Keywords: LXR، گیرنده کبد X; BDL, bile duct ligation; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; FXR, Farnesoid X Receptor; LCA, lithocholic acid; LXR, liver X receptor; NR, nuclear receptor; PBC, primary biliary cirrhosis; PCN, pregnenolone 16α-carbonitrile
CIDEA interacts with liver X receptors in white fat cells
Keywords: LXR، گیرنده کبد X; CIDEA, cell death-inducing DNA fragmentation factor alpha-like effector A; DBD, DNA binding domain; GFP, green fluorescence protein; GST, glutathione S-transferase; LXR, liver X receptor; PPARγ, peroxisome proliferator-activated receptor γNuclear receptor
Synthesis of the enantiomer of the oxysterol-antagonist LY295427
Keywords: LXR، گیرنده کبد X; 25-HC, 25-hydroxycholesterol; LXR, liver X receptor; ACAT, acylCoA: cholesterol acyl transferase; HMGR, HMG-CoA reductase; SREBP, sterol regulatory element binding protein; ent, enantiomer; nat, naturalEnantiomer; Oxysterol; LY295427
Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors
Keywords: LXR، گیرنده کبد X; LXR, liver X receptor; VLDL, very low density lipoprotein; Apo B, apolipoprotein B; SREBP, sterol regulatory element binding protein; CYP7A1, cholesterol 7 alpha-hydroxylase; HMGR, 3-hydroxy-3-methylglutaryl CoA reductase; LDLr, low-density lipoprotein re
Unsaturated fatty acids repress the expression of ATP-binding cassette transporter A1 in HepG2 and FHs 74 Int cells
Keywords: LXR، گیرنده کبد X; apoA-I, apolipoprotein A-I; ABCA1, adenosine triphosphate–binding cassette transporter A1; CVD, cardiovascular disease; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; HDL, high-density lipoprotein; LDL, low-density lipoprotein; LXR, liver X receptor;
Lycopene regulation of cholesterol synthesis and efflux in human macrophages
Keywords: LXR، گیرنده کبد X; ABC, ATP-binding cassette; cav-1, caveolin-1; GGPP, geranylgeranyl pyrophosphate; HMG-CoA, 3-hydroxy-3-methylglutaryl coenzyme A; LXR, liver X receptor; PMA, phorbol 22-myristate 13-acetate; PPAR, peroxisome proliferator-activated receptor; THF, tetrahydr
Biliary Sterol Secretion Is Required for Functional In Vivo Reverse Cholesterol Transport in Mice
Keywords: LXR، گیرنده کبد X; Liver; Atherosclerosis; Lipid; Intestine; Bile Acidsabcb4, adenosine triphosphate binding cassette transporter B4; BDL, bile duct ligation; FCR, fractional catabolic rate; HDL, high-density lipoproteins; LXR, liver X receptor; RCT, reverse cholesterol tra
Sex differences in nuclear receptor-regulated liver metabolic pathways
Keywords: LXR، گیرنده کبد X; NRs, nuclear receptors; ER, estrogen receptor; AR, androgen receptor; GR, glucocorticoid receptor; RXR, retinoic X receptor; LXR, liver X receptor; PPAR, peroxisome proliferator activated receptor; TR, thyroid hormone receptor; PXR, pregnane X receptor; C
The molecular basis of nutritional intervention in multiple sclerosis: A narrative review
Keywords: LXR، گیرنده کبد X; PPAR, peroxisome proliferator activated receptor; LXR, liver X receptor; RXR, retinoid X-receptor; NF-kB, nuclear transcription factor-kB; SREBP, steroid regulatory element-binding protein; ChREBP, carbohydrate responsive element-binding protein; SIRT-1/2
Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease
Keywords: LXR، گیرنده کبد X; Nuclear Receptors; LXRs; Hepatic Stellate Cells; Liver FibrosisDAPI, 4′,6-diamidino-2-phenylindole; DMEM, Dulbecco's modified Eagle medium; LXR, liver X receptor; MCD, methionine/choline-deficient; TGF, transforming growth factor; TNF, tumor necrosis fact
Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice
Keywords: LXR، گیرنده کبد X; Abcg8, ATP binding cassette transporter G8; BW, body weight; FNS, faecal neutral sterols; LXR, liver X receptor; NPC1L1, Niemann-Pick C1 Like 1; PPARd, peroxisome proliferator activated receptor delta; RCT, reverse cholesterol transport; TICE, trans-intes
Molecular determinants of the interactions between SRC-1 and LXR/RXR heterodimers
Keywords: LXR، گیرنده کبد X; 9cisRA, 9-cis retinoic acid; 22ROHC, 22(R)-hydroxycholesterol; AF2, activation function 2; MBP, maltose-binding protein; LBD, ligand-binding domain; LXR, liver X receptor; NR, nuclear receptor; NR box-1/-2/-3, the first/second/third NR box of SRC-1, respe
FoxO1 represses LXRα-mediated transcriptional activity of SREBP-1c promoter in HepG2 cells
Keywords: LXR، گیرنده کبد X; SREBPs, sterol regulatory element binding proteins; FoxO, forkhead box-“Other”; Akt/PKB, protein kinase B; PPARα, peroxisome proliferator-activated receptor-α; RXR, retinoid X receptor; LXR, liver X receptor; FASN, fatty acid synthase; LXREs, LXR responsi
Intrahepatic cholesterol influences progression, inhibition and reversal of non-alcoholic steatohepatitis in hyperlipidemic mice
Keywords: LXR، گیرنده کبد X; NASH, non-alcoholic steatohepatitis; LXR, liver X receptor; APOE2ki, humanized apolipoprotein E2 knock-in; NAFLD, non-alcoholic fatty liver disease; LDL, low density lipoprotein; HFC, high fat, high cholesterol; FF, fenofibrate; PPARα, peroxisome prolifer
Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes
Keywords: LXR، گیرنده کبد X; ApoM, apolipoprotein M; LXR, liver X receptor; RCT, reverse cholesterol transport; HDL, high density lipoprotein; TNF, tumor necrosis factor; HNF-1α, hepatocyte nuclear factor-1α; LRH-1, liver receptor homolog-1; Foxa2, forkhead box A2; TGF-β, transformin
PPARγ regulates the expression of cholesterol metabolism genes in alveolar macrophages
Keywords: LXR، گیرنده کبد X; PPARγ, peroxisome proliferator-activated receptor-gamma; ABC, ATP-binding cassette; PAP, pulmonary alveolar proteinosis; GM-CSF, granulocyte–macrophage colony-stimulating factor; BAL, bronchoalveolar lavage; LXR, liver X receptor; ApoE, apolipoprotein E;
PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells
Keywords: LXR، گیرنده کبد X; ABCA1, ATP-binding cassette transporter A1; HDL, high-density lipoproteins; LXR, liver X receptor; LXRE, LXR response element; PPAR, peroxisome proliferator-activated receptorABCA1; HDL; LXR; MEK1/2; PPARγ
Proton pump inhibitor Lansoprazole is a nuclear liver X receptor agonist
Keywords: LXR، گیرنده کبد X; LXR, liver X receptor; PPI, proton pump inhibitor; ABCA1, ATP binding cassette transporter A1; CompL, Lansoprazole; Aβ, amyloid β; RXR, retinoid X receptor; IFN, interferon; NSAID, non-steroidal antiinflammatory drugLiver X receptors; Proton pump inhibito
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein
Keywords: LXR، گیرنده کبد X; LXR, liver X receptor; LDL, low density lipoprotein; oxLDL, oxidized LDLLXR agonist; TO901317; Ovarian cancer; Oxidized LDL; Chemoresistance; Statin; Fluvastatin
LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms
Keywords: LXR، گیرنده کبد X; ABCA1, ATP-binding cassette, sub-family A (ABC1), member 1; ABCG1, ATP-binding cassette, sub-family G (WHITE), member 1; ERK, extracellular signal-regulated kinase; ICAM1, intercellular adhesion molecule 1; IL8, interleukin 8; LXR, liver X receptor; SELE,
Micellar lipid composition profoundly affects LXR-dependent cholesterol transport across CaCo2 cells
Keywords: LXR، گیرنده کبد X; ABC, ATP-binding casette; DMEM, Dulbecco’s minimum essential medium; FCS, fetal calf serum; HDL, high density lipoprotein; LysoPC, Lyso-phosphatidylcholine; LXR, liver X receptor; NPC1L1, Niemann-Pick C1-like-1; PC, Phosphatidylcholine; RXR, retinoid X re