کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2580370 1561617 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biological effects of conjugated linoleic acid on obesity-related cancers
ترجمه فارسی عنوان
اثرات بیولوژیکی اسید لینولئیک کانژوگه بر سرطان های مرتبط با چاقی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Obesity and overweight play an important role in cancers.
• CLA has anti-carcinogenic effects.
• CLA is a useful agent in the chemoprevention of obesity-related cancers.
• Future work is needed to investigate CLA’s safety for applications to human.

Considerable evidence suggests that obesity and overweight play an important role in cancers i.e., breast, colon, endometrial, kidney, pancreatic, and liver. In fact, overweight and obesity are now established risk factors for cancer and cancer-related mortality. Conjugated linoleic acid (CLA) consists of a group of positional and geometric fatty acid (FA) isomers that are derived from linoleic acid (LA) [18:2(n-6)], which occurs naturally in food with a high concentration in products from ruminant animals. Studies in both in vitro cell and in vivo animal models have shown that CLA, specifically cis 9-trans 11 and trans 10-cis 12 CLA isomer, inhibits the initiation and promotion stages of carcinogenesis, suggesting that CLA has received considerable attention as a chemopreventive agent. In this review, the biological activities and multiple mechanisms of CLA in obesity-related cancers including cell lines, animal models and clinical observations are explained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 224, 5 December 2014, Pages 189–195
نویسندگان
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