کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053152 1074260 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
p38 MAPK is involved in CB2 receptor-induced apoptosis of human leukaemia cells
چکیده انگلیسی

Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen-activated protein kinases (MAPKs) in CB2 receptor-induced apoptosis of human leukaemia cells. Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor-induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 22, 12 September 2005, Pages 5084–5088
نویسندگان
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