کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2053298 1074270 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin
چکیده انگلیسی

The G6b gene, located in the human Major Histocompatibility Complex, encodes a receptor of the immunoglobulin (Ig) superfamily. In this study, we show using a variety of techniques that the extracellular domain of the G6b protein, containing a single Ig-like domain, binds to heparin with high affinity. In an ELISA assay, this binding was displaceable with soluble heparin with an IC50 value of approximately 0.5 μg/ml. Other sulfated glycans showed weaker or no competition. The observed interaction between G6b and heparin is strongly salt dependent suggesting a mainly electrostatic interaction. Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 579, Issue 11, 25 April 2005, Pages 2355–2358
نویسندگان
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