کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2055477 1543886 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis
ترجمه فارسی عنوان
هیدروژن دیسیتلیسیون، عامل تعیین کننده سلولی در Arabidopsis است
کلمات کلیدی
AGL15، AGAMOUS-LIKE 15؛ ARR، ARABIDOPSIS تنظیم کننده پاسخ؛ BBM، BABY BOOM؛ CIM، کالوس القا کننده؛ HDAC، HISTONE DEACETYLASE؛ HDT، HD-TUINS پروتئین؛ LBD، LOMERAL ORGAN DOMAIN BORDERS؛ LEC1، LEAFY COTYLEDON 1؛ PcG، گروه پلی کامب؛ PRC، polycomb r
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم زراعت و اصلاح نباتات
چکیده انگلیسی

Chromatin structure determines the accessibility of transcriptional regulators to target DNA and contributes to regulation of gene expression. Posttranslational modifications of core histone proteins underlie the reversible changes in chromatin structure. Epigenetic regulation is closely associated with cellular differentiation. Consistently, we found that histone deacetylation is required for callus formation from leaf explants in Arabidopsis . Treatment with trichostatin A (TSA) led to defective callus formation on callus-inducing medium (CIM). Gene expression profiling revealed that a subset of HDAC genes, including HISTONE DEACETYLASE 9 (HDA9), HD-TUINS PROTEIN 1 (HDT1), HDT2, HDT4, and SIRTUIN 1 (SRT1), was significantly up-regulated in calli. In support of this, genetic mutations of HDA9 or HDT1 showed reduced capability of callus formation, probably owing to their roles in regulating auxin and embryonic and meristematic developmental signaling. Taken together, our findings suggest that histone deacetylation is intimately associated with the leaf-to-callus transition, and multiple signaling pathways are controlled by means of histone modification during cellular dedifferentiation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Plant Physiology - Volume 191, 1 February 2016, Pages 95–100
نویسندگان
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