The L-amino acid oxidase from Calloselasma rhodostoma snake venom modulates apoptomiRs expression in Bcr-Abl-positive cell lines

• CR-LAAO regulates apoptotic machinery in Bcr-Abl+ cells by apoptomiRs modulation.
• CR-LAAO modulates Bid, Bim, Bcl-2, Ciap-2, c-Flip and Mcl-1 levels in Bcr-Abl+ cells.
• CR-LAAO is a potential tool to investigate the apoptomiRs regulation in tumor cells.
• CR-LAAO effect in Bcr-Abl+ cells may drive a description of targets for CML therapy.

Anti-apoptotic genes and apoptomiRs deregulated expression contribute to apoptosis resistance in chronic myeloid leukemia (CML) Bcr-Abl+ cells. Here, the L-amino acid oxidase from Calloselasma rhodostoma (CR-LAAO) venom altered the apoptotic machinery regulation by modulating the expression of the miR-145, miR-26a, miR-142-3p, miR-21, miR-130a, and miR-146a, and of the apoptosis-related proteins Bid, Bim, Bcl-2, Ciap-2, c-Flip, and Mcl-1 in Bcr-Abl+ cells. CR-LAAO is a potential tool to instigate apoptomiRs regulation that contributes to drive CML therapy.