کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2066542 1077230 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of urinary metabolites from four synthetic bradykinin potentiating peptides (BPPs) in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Characterization of urinary metabolites from four synthetic bradykinin potentiating peptides (BPPs) in mice
چکیده انگلیسی

BPPs have been identified in the venom of the Bothrops jararaca snake, or deduced from precursor proteins expressed either in the venom gland or in the brain of the snake. Their potentiating activity on bradykinin (Bk) is assumed to occur through a somatic angiotensin-converting enzyme (sACE) inhibitory mechanism. We have demonstrated that synthetic BPPs show remarkable functional differences, despite their high amino acid sequence similarities. Recently, we demonstrated that BPP-10c, after i.p. administration, was found in its intact form and in the form of a unique metabolite (des-Pro10 BPP-10c) in mouse urine. Given this finding, we selected a number of BPPs with different structure-activities – BPP-5a (

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicon - Volume 52, Issue 3, 1 September 2008, Pages 501–507
نویسندگان
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