کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067561 | 1077899 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Post-conditioning exacerbates the MnSOD immune-reactivity after experimental cerebral global ischemia and reperfusion in the rat brain hippocampus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
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چکیده انگلیسی
This study monitored the effects of sub-lethal ischemia (post-conditioning) applied after a previous ischemic attack by way of the MnSOD immune-reactivity examined in CA1 and dentate gyrus of the rat hippocampus. The experimental 10Â min transient cerebral ischemia was followed by 2Â days of reperfusion, the rats then underwent a second ischemia (4 or 6Â min post-conditioning). MnSOD immune-reactivity was evaluated after 5Â h, 1 and 2Â days. Results obtained by computer microdensitometric image analysis indicated that 4Â min of ischemic post-conditioning caused higher MnSOD immune-reactivity than 6Â min. However, higher viability of CA1 neurons after stronger (6Â min) post-conditioning when production of MnSOD is lower, as well as differences between MnSOD in CA1 and dentate gyrus indicates another mechanism switching pro-apoptotic destination of CA1 neurons to anti-apoptotic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 32, Issue 1, January 2008, Pages 128-135
Journal: Cell Biology International - Volume 32, Issue 1, January 2008, Pages 128-135
نویسندگان
Miroslava Nemethova, Viera Danielisova, Miroslav Gottlieb, Jozef Burda,