کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067634 | 1077902 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells](/preview/png/2067634.png)
چکیده انگلیسی
A non-transformed (Vero) and two tumor cell lines (HepG2 and MCF-7) were treated with 10 nM to 100 μM formaldehyde. Lower doses (10 nM to 10 μM) enhanced the viability of the cultured cells, measured by MTT assay. Higher doses (75-100 μM) decreased viability of the cells by 50% or more. The 100 μM concentration of HCHO has been chosen for combination treatment of the three cell lines with a series of concentrations (0.2-100 μM) of resveratrol, a phytoestrogen occurring in various fruits. Resveratrol decreased the cytotoxicity of formaldehyde depending on cell line and point of time, especially in case of MCF-7 cells at 24 and 72 h, Vero cells at 24 h and HepG2 cells at 48 h after treatment. Possible modes of interactions are discussed, considering the role of resveratrol in formaldehyde metabolism and also the estrogen receptor positivity of MCF-7 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 31, Issue 10, October 2007, Pages 1214-1219
Journal: Cell Biology International - Volume 31, Issue 10, October 2007, Pages 1214-1219
نویسندگان
Z.L. Marcsek, Zs. Kocsis, B. Szende, A. Tompa,