کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2067651 1544340 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Direct association between caspase 3 and α5β1 integrin and its role during anoikis of rat fibroblasts
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Direct association between caspase 3 and α5β1 integrin and its role during anoikis of rat fibroblasts
چکیده انگلیسی
We have demonstrated a direct association between α5β1 integrin and caspase 3, both pro- and mature enzyme, in various sub-cellular compartments of rat fibroblasts undergoing anoikis. Integrin associated caspase 3 showed high activity in the plasma membranes, whereas in the cytosol and microsomal fraction it showed little or no activity. Our results suggest a possible role for recycled un-ligated α5β1 integrin molecules between cytosol and plasma membrane, in regulation of caspase-3 activity and induction of cell death in adhesion-deprived cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 30, Issue 12, December 2006, Pages 963-969
نویسندگان
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