کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067801 | 1077911 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transformation by RAS oncogene decreases the width of substrate-spread fibroblasts but not their length
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transformation by RAS oncogene decreases the width of substrate-spread fibroblasts but not their length Transformation by RAS oncogene decreases the width of substrate-spread fibroblasts but not their length](/preview/png/2067801.png)
چکیده انگلیسی
We compared morphometric parameters of the contours of cells in four pairs of non-transformed mouse and rat lines and of the same lines transformed by oncogenes of the RAS family. As expected, the mean areas of all RAS-transformed lines were much smaller than those of their non-transformed counterparts. At the same time the average length of cell projection did not regularly decrease after transformation. These results show that transformation induced by expression of RAS oncogene selectively affect only one component of spreading, namely transversal spreading and not longitudinal spreading; these changes result in an increase of antero-posterior polarity of transformed fibroblasts.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 31, Issue 3, March 2007, Pages 220-223
Journal: Cell Biology International - Volume 31, Issue 3, March 2007, Pages 220-223
نویسندگان
Margarita A. Kharitonova, Pavel B. Kopnin, Jury M. Vasiliev,