کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2067934 | 1077919 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calmodulin is essential for angiogenesis in response to hypoxic stress in endothelial cells
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کلمات کلیدی
PBSDMEMTFPLamellipodiaHREHIFBSA - BSADulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده Dulbeccobovine serum albumin - آلبومین سرم گاوAngiogenesis - آنژیوژنزactin - اکتین Trifluoperazine - تریفلوپرازینCAM - ساخت به کمک کامپیوترhypoxia inducible factor-1 - عامل القایی هیپوکسی 1hypoxia response element - عنصر پاسخ هیپوکسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Hypoxia Inducible Factor - فاکتور قابل تشخیص هیپوکسیphosphate buffer saline - فسفات بافر شورHypoxia - هیپوکسیCalmodulin - کالمودولین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Angiogenesis, the formation of new blood vessels that is regulated by hypoxia, is a critical process for the growth and spread of tumors. Multiple phases of this process, including migration, adhesion, and formation of new capillary tubes, are needed for optimal tumor growth. Here, a new regulatory function for Ca2+-CaM in the vascular endothelium is described. Ca2+-CaM activation induced by hypoxia in endothelial cells is essential for angiogenic cellular responses. Inhibition of Ca2+-CaM activity suppressed endothelial cell migration, adhesion on collagen I substrate, invasion and impaired in vitro endothelial cell differentiation into tube-like structures. We also reported that CaM is co-distributed with the actin structures in the lamellipodia in migrating cells, whereas the actin cytoskeleton rearrangement induced by hypoxia was disrupted and HIF-1 transcriptional activity was decreased when treated with CaM antagonists into cultures. These data indicate that Ca2+-CaM activation is more closely associated with the regulation of angiogenic key events, especially in response to hypoxic stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Biology International - Volume 31, Issue 2, February 2007, Pages 126-134
Journal: Cell Biology International - Volume 31, Issue 2, February 2007, Pages 126-134
نویسندگان
Wei-Gan Shen, Wan-Xin Peng, Gu Dai, Jian-Feng Xu, Yu Zhang, Chao-Jun Li,