کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2068781 1078353 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
GRIM-19 function in cancer development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
GRIM-19 function in cancer development
چکیده انگلیسی

Cancer development involves multiple genetic changes, which can occur in tumor suppressor genes and lead to loss of function in a recessive manner. Recent findings have identified a novel tumor suppressor gene named GRIM-19. Similar to what has been observed for other known tumor suppressor proteins such as p53, GRIM-19 gene mutations and loss of protein expression have been observed in several tumor types. In this review, we perform a detailed description on the current understanding of GRIM-19 function in carcinogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 11, Issue 5, September 2011, Pages 693–699
نویسندگان
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