کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2069129 | 1078374 | 2006 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impaired platelet mitochondrial activity in Alzheimer’s disease and mild cognitive impairment
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوفیزیک
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چکیده انگلیسی
Mitochondrial abnormalities are found in Alzheimer’s disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 6, Issue 6, December 2006, Pages 323–330
Journal: Mitochondrion - Volume 6, Issue 6, December 2006, Pages 323–330
نویسندگان
Jon Valla, Lonnie Schneider, Tracy Niedzielko, Keith D. Coon, Richard Caselli, Marwan N. Sabbagh, Geoffrey L. Ahern, Leslie Baxter, Gene Alexander, Douglas G. Walker, Eric M. Reiman,