کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2069129 1078374 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impaired platelet mitochondrial activity in Alzheimer’s disease and mild cognitive impairment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Impaired platelet mitochondrial activity in Alzheimer’s disease and mild cognitive impairment
چکیده انگلیسی

Mitochondrial abnormalities are found in Alzheimer’s disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 6, Issue 6, December 2006, Pages 323–330
نویسندگان
, , , , , , , , , , ,