کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070709 1544565 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent advances in the characterization of amorphous pharmaceuticals by X-ray diffractometry
ترجمه فارسی عنوان
پیشرفت های اخیر در توصیف داروهای آمورف توسط اشعه ایکس دفرکتومی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

For poorly water soluble drugs, the amorphous state provides an avenue to enhance oral bioavailability. The preparation method, in addition to sample history, can dictate the nature and the stability of the amorphous phase. Conventionally, X-ray powder diffractometry is of limited utility for characterization, but structural insights into amorphous and nanocrystalline materials have been enabled by coupling X-ray total scattering with the pair distribution function. This has shown great promise for fingerprinting, quantification, and even modeling of amorphous pharmaceutical systems. A consequence of the physical instability of amorphous phases is their crystallization propensity, and recent instrumental advances have substantially enhanced our ability to detect and quantify crystallization in a variety of complex matrices. The International Centre for Diffraction Data has a collection of the X-ray diffraction patterns of amorphous drugs and excipients and, based on the available supporting information, provides a quality mark of the data.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 100, 1 May 2016, Pages 183–193
نویسندگان
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