کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2070716 1078683 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roles of signaling and transcriptional networks in pathological lymphangiogenesis
ترجمه فارسی عنوان
نقش شبکه های سیگنالینگ و رونویسی در لنفانژیوژنز آسیب شناسی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
چکیده انگلیسی

Lymphangiogenesis, the generation of new lymphatic vessels, plays important roles in cancer metastasis. Outstanding progress during the past decade has dramatically increased the novel knowledge and insights of the mechanisms underlying the generation of new lymphatic vessels, the roles of transcription factors and lymphangiogenic growth factors during physiological development and pathological processes such as cancer and inflammation. Furthermore, an understanding of the molecular consequences during tumor lymphangiogenesis has provided chances to develop better diagnostic and therapeutic approaches that aim to limit the progression of cancer. In this article, we will explain the current knowledge of how lymphatic function is altered in various pathological conditions including cancer progression.

Roles of positive and negative regulators of lymphangiogenesis during cancer metastasis. Cancer cells and infiltrating immune cells in primary tumor produce various factors that regulate lymphangiogenesis positively (e.g. VEGF-C/D) and negatively (TGF-β and BMP-9). Generation and remodeling of new lymphatic vessels promote the tumor cells to metastasize to lymph nodes and eventually to distant organs. Understanding the signaling and transcriptional networks regulating these processes will aid in developing novel therapeutic strategies for cancer.Figure optionsDownload high-quality image (270 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 99, Part B, 1 April 2016, Pages 161–171
نویسندگان
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