کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071015 1078716 2013 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells
چکیده انگلیسی

Among 12 billion injections administered annually, unsafe delivery leads to > 20 million infections and > 100 million reactions. In an emerging new concept, freeze-dried plant cells (lettuce) expressing vaccine antigens/biopharmaceuticals are protected in the stomach from acids/enzymes but are released to the immune or blood circulatory system when plant cell walls are digested by microbes that colonize the gut. Vaccine antigens bioencapsulated in plant cells upon oral delivery after priming, conferred both mucosal and systemic immunity and protection against bacterial, viral or protozoan pathogens or toxin challenge. Oral delivery of autoantigens was effective against complications of type 1 diabetes and hemophilia, by developing tolerance. Oral delivery of proinsulin or exendin-4 expressed in plant cells regulated blood glucose levels similar to injections. Therefore, this new platform offers a low cost alternative to deliver different therapeutic proteins to combat infectious or inherited diseases by eliminating inactivated pathogens, expensive purification, cold storage/transportation and sterile injections.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 65, Issue 6, 15 June 2013, Pages 782–799
نویسندگان
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