کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071085 1078721 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Qualitative and quantitative mass spectrometry imaging of drugs and metabolites
چکیده انگلیسی

Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical sciences. While quantitative whole-body autoradiography and microautoradiography are the traditional techniques for molecular imaging of drug delivery and metabolism, MSI provides advantageous specificity that can distinguish the parent drug from metabolites and modified endogenous molecules. This review begins with the fundamentals of MSI sample preparation/ionization, and then moves on to both qualitative and quantitative applications with special emphasis on drug discovery and delivery. Cutting-edge investigations on sub-cellular imaging and endogenous signaling peptides are also highlighted, followed by perspectives on emerging technology and the path for MSI to become a routine analysis technique.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 65, Issue 8, July 2013, Pages 1074–1085
نویسندگان
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