کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2071085 | 1078721 | 2013 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Qualitative and quantitative mass spectrometry imaging of drugs and metabolites Qualitative and quantitative mass spectrometry imaging of drugs and metabolites](/preview/png/2071085.png)
Mass spectrometric imaging (MSI) has rapidly increased its presence in the pharmaceutical sciences. While quantitative whole-body autoradiography and microautoradiography are the traditional techniques for molecular imaging of drug delivery and metabolism, MSI provides advantageous specificity that can distinguish the parent drug from metabolites and modified endogenous molecules. This review begins with the fundamentals of MSI sample preparation/ionization, and then moves on to both qualitative and quantitative applications with special emphasis on drug discovery and delivery. Cutting-edge investigations on sub-cellular imaging and endogenous signaling peptides are also highlighted, followed by perspectives on emerging technology and the path for MSI to become a routine analysis technique.
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Journal: Advanced Drug Delivery Reviews - Volume 65, Issue 8, July 2013, Pages 1074–1085