کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071454 1078750 2010 52 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery
چکیده انگلیسی

This review presents the structure and physico-chemical properties of ECMPs, elastic-contractile model proteins using sparse design modifications of elastic (GVGVP)n; it describes the capacity of ECMP to perform the energy conversions that sustain living organisms; it arrives at the hydration thermodynamics of ECMP in terms of the change in Gibbs free energy of hydrophobic association, ΔGHA, and the apolar–polar repulsive free energy of hydration, ΔGap; it applies ΔGHA, ΔGap, and the nature of elasticity to describe the function of basic diverse proteins, namely — the F1-motor of ATP synthase, Complex III of mitochondria, the KscA potassium-channel, and the molecular chaperonin, GroEL/ES; it applies ΔGHA and ΔGap to describe the function of ABC exporter proteins that confer multi-drug resistance (MDR) on micro-organisms and human carcinomas and suggests drug modifications with which to overcome MDR. Using ECMP, means are demonstrated, for quantifying drug hydrophobicity with which to combat MDR and for preparing ECMP drug delivery nanoparticles, ECMPddnp, decorated with synthetic antigen-binding fragments, Fab1 and Fab2, with which to target specific up-regulated receptors, characteristic of human carcinoma cells, for binding and localized drug release.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 62, Issue 15, 30 December 2010, Pages 1404–1455
نویسندگان
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