کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2071555 1078758 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوتکنولوژی یا زیست‌فناوری
پیش نمایش صفحه اول مقاله
Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines
چکیده انگلیسی

The discovery of new molecular targets and the subsequent development of novel anticancer agents are opening new possibilities for drug combination therapy as anticancer treatment. Polymer–drug conjugates are well established for the delivery of a single therapeutic agent, but only in very recent years their use has been extended to the delivery of multi-agent therapy. These early studies revealed the therapeutic potential of this application but raised new challenges (namely, drug loading and drugs ratio, characterisation, and development of suitable carriers) that need to be addressed for a successful optimisation of the system towards clinical applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advanced Drug Delivery Reviews - Volume 61, Issue 13, 12 November 2009, Pages 1203–1213
نویسندگان
, ,