کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2071849 | 1078778 | 2008 | 12 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications](/preview/png/2071849.png)
Alpha particle-emitting isotopes have been proposed as novel cytotoxic agents for augmenting targeted therapy. Properties of alpha particle radiation such as their limited range in tissue of a few cell diameters and their high linear energy transfer leading to dense radiation damage along each alpha track are promising in the treatment of cancer, especially when single cells or clusters of tumor cells are targeted. Actinium-225 (225Ac) is an alpha particle-emitting radionuclide that generates 4 net alpha particle isotopes in a short decay chain to stable 209Bi, and as such can be described as an alpha particle nanogenerator. This article reviews the literature pertaining to the research, development, and utilization of targeted 225Ac to potently and specifically affect cancer.
Journal: Advanced Drug Delivery Reviews - Volume 60, Issue 12, 15 September 2008, Pages 1371–1382